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- W51630404 abstract "The main events in lung development include branching morphogenesis to form the bronchial tree and formation and expansion of the air–blood barrier for gas exchange. Many pediatric lung diseases and malformations can be understood through the examination of normal development. The main factors influencing airway branching are signaling from the mesenchyme to the epithelium and intraluminal fluid pressure. Defects in these processes can lead to pulmonary hypoplasia as well as tracheoesophageal fistulas, bronchogenic cysts, pulmonary sequestrations, and congenital pulmonary airway malformations. Air–blood barrier formation requires proliferation of capillaries, a decrease in the mesenchyme, and differentiation of type I and II pneumocytes. Extreme premature birth is a risk factor for defects in these processes and can lead to bronchopulmonary dysplasia. The transition from an aqueous intrauterine environment to breathing air requires a mature surfactant to reduce surface tension. Multiple genetic defects in surfactant proteins and metabolism have been recently described." @default.
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- W51630404 date "2014-01-01" @default.
- W51630404 modified "2023-09-29" @default.
- W51630404 title "Pulmonary Development and Pediatric Lung Diseases" @default.
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- W51630404 doi "https://doi.org/10.1016/b978-0-12-386456-7.05303-x" @default.
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