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- W51751571 abstract "The hormonal relationship that Cramer and Horning (6, 8, 9) believe to exist between brown degeneration of the adrenals and carcinoma of the mammae in high tumor strain mice has been questioned by other observers, but not definitely disproved. Details may be found in the papers of Dobrovolska~a-Zavadskaia and her group (15-17); Lacassagne and Raynaud (25, 26); Blaisdell, Gardner, and Strong (1); Bonser (3); and Kreyberg (23). This degeneration occurs frequently at an early age in female mice of a high tumor strain, according to Cramer (8) and Dobrovolskai'a-Zavadskai'a (17), but is seen also in the tumorfree males of the same strain at a later age. It has been described by Whitehead (31), Martin (28), Howard-Miller (21 ), Burrows (5), Daughady (11), and Deanesly (12) as seen at the cortico-medullary junction, in the periphery of the medulla, or in the medial part of the zona reticularis. The change significantly begins in the x-zone, which, according to Howard-Miller, is A transitory zone showing age and sex relationships in The appearance of brown degeneration around the x-zone in various strains of mice after estrinization as described by Burrows (4, 5), Cramer (6), and Martin (28), and the induction of mammary tumors in similar strains also by estrinization reported by Cramer (10), Bonser and her associates (2), Lacassagne (24), Twombly (30), and Gardner (18) warranted further studies on this apparent relationship. Burrows (5) states that the effect of castration, pregnancy, and estrogen on the presence or absence of the x-zone suggests that it may be influenced by testosterone or progesterone, and notes that these hormones seem to hasten the involution or absorption that normally occurs in the x-zone of adrenals in female mice. Deanesly points out that castration of the male causes reappearance of the x-zone, converting the male adrenal to the female type. Woolley, Fekete, and Little (32) have observed nodular hyperplasia and carcinoma of the adrenals in ovariectomized mice that show a return of estrogen effect. Martin (28) noted the dis-" @default.
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- W51751571 date "1944-01-01" @default.
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- W51751571 title "Effect of Testosterone Propionate on the Adrenals and on the Incidence of Mammary Cancer in the RIII Strain of Mice" @default.
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