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- W51776685 abstract "Abstract IL-21 and IL-4 bind overlapping epitopes on the common γ-chain, and IL-21 is reported to inhibit DC maturation and function in a murine model. To investigate the role of IL-21 on different stages of DC, monocyte derived immature dendritic cells (iDC) were generated in GMCSF and IL-4 in the presence and absence of IL-21, 20ng/mL for 5 days, termed as IL-21 iDC and control (c) iDC. IL-21iDC had significantly higher CD83 expression than ciDC on Day 5 (n=5, P<0.004) with equivalent CD86 and HLADR expression. IL21iDC had 30–50 times greater PD-L1 mRNA expression compared to ciDC as quantified by real-time PCR, but with similar expression of SOCS-1 mRNA at three doses of IL21 (20,50,100ng/ml). Day 5 iDC were further matured by the addition of maturation cocktail (TNF-α, IL1β and PGE2) for 2 days. Day7 cDC and IL-21DC expressed high PD-L1 and did not differ in their expression of phenotypic markers. Autologous T cell response to flu antigen presenting cell (APC) function of IL-21DC was 2.6 fold greater (IFN-γ Elispot response) than of cDC, whereas allogeneic T cells had a similar MLR proliferative response to IL21DC as to cDC. We conclude that IL-21 enhances iDC differentiation with mild augmentation of mDC APC function. DC maturation under optimal culture conditions is unaffected by IL-21. Source of Research Support: Institutional Support" @default.
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- W51776685 date "2007-04-01" @default.
- W51776685 modified "2023-09-23" @default.
- W51776685 title "IL-21 augments Monocyte Derived Dendritic Cell (mDC) maturation and upregulates PD-L1 gene expression (47.37)" @default.
- W51776685 doi "https://doi.org/10.4049/jimmunol.178.supp.47.37" @default.
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