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- W51916057 abstract "A summary of the development of extracellular MRI contrast agents during the last twenty years is given. Focal points are chemistry, physico-chemical properties and pharmacokinetic behaviour of gadolinium complexes. The synthesis of acyclic and macrocyclic ligands is described, particularly of derivatives of the ligands DTPA and DOTA. Stability, relaxivity and formulations of the gadolinium complexes are issues of special interest as well as their toxicological and clinical aspects. An outlook on the future development of clinically useful extracellular MRI contrast agents is provided." @default.
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- W51916057 date "2002-01-01" @default.
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- W51916057 title "Extracellular MRI Contrast Agents Based on Gadolinium" @default.
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- W51916057 doi "https://doi.org/10.1007/3-540-45733-x_1" @default.
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