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- W51998161 abstract "The term 'chronic active hepatitis' (CAH), first used by Saint et al. (1953) to describe a progressive inflammatory liver disease predominantly affecting young women and having a poor prognosis, is now used to describe a spectrum of aetiologically distinct diseases with a very similar histological picture. This is characterized by an intense portal tract mononuclear cell infiltrate spreading into the liver parenchyma and disrupting the limiting plate of periportal hepatocytes. Liver cells in this part of the lobule are generally isolated and surrounded by mononuclear cells, features described as 'piecemeal' necrosis. The parenchyma tends to be subdivided by fibrous septa accompanying the inflammation and linking portal tracts to each other or to central veins; this, together with the appearance of nodules of regenerating hepatocytes, leads to the development of cirrhosis. Several different aetiological stimuli may be responsible for the appearance of the characteristic liver lesions of chronic active hepatitis, including non-A, non-B virus infection, Wilson's disease and alpha-l-antitrypsin deficiency. However, the three varieties of the disease most intensively investigated are the 'autoimmune' type (having features in common with the group of organspecific autoimmune diseases), the hepatitis B virus (HBV)-related type and the drug-induced variety. After summarizing the main characteristics of these varieties, we will compare and contrast the immunological phenomena which could be responsible for the liver cell damage in these three types of CAH." @default.
- W51998161 created "2016-06-24" @default.
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- W51998161 date "1987-05-01" @default.
- W51998161 modified "2023-09-23" @default.
- W51998161 title "Immunological aspects of chronic active hepatitis." @default.
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