Matches in SemOpenAlex for { <https://semopenalex.org/work/W52003657> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W52003657 endingPage "41" @default.
- W52003657 startingPage "1533" @default.
- W52003657 abstract "The treatment of spinal cord injury is still a challenge. This study aimed at evaluating the therapeutical effectiveness of neurons derived form mesenchymal stem cells (MSCs) for spinal cord injury.In this study, rhesus MSCs were isolated and induced by cryptotanshinone in vitro and then a process of RT-PCR was used to detect the expression of glutamic acid decarboxylase (GAD) gene. The induced MSCs were tagged with Hoechst 33342 and injected into the injury site of rhesus spinal cord made by the modified Allen method. Following that, behavior analysis was made after 1 week, 1 month, 2 months and 3 months. After 3 months, true blue chloride retrograde tracing study was also used to evaluate the re-establishment of axons pathway and the hematoxylin-eosin (HE) staining and immunohistochemistry were performed after the animals had been killed.In this study, the expression of mRNA of GAD gene could be found in the induced MSCs but not in primitive MSCs and immunohistochemistry could also confirm that rhesus MSCs could be induced and differentiated into neurons. Behavior analysis showed that the experimental animals restored the function of spinal cord up to grade 2-3 of Tarlov classification. Retrograde tracing study showed that true blue chollide could be found in the rostral thoracic spinal cords, red nucleus and sensory-motor cortex.These results suggest that the transplantation is safe and effective." @default.
- W52003657 created "2016-06-24" @default.
- W52003657 creator A5003551515 @default.
- W52003657 creator A5019009434 @default.
- W52003657 creator A5032221349 @default.
- W52003657 creator A5036522440 @default.
- W52003657 creator A5050789305 @default.
- W52003657 creator A5069736511 @default.
- W52003657 creator A5075596275 @default.
- W52003657 date "2005-09-20" @default.
- W52003657 modified "2023-10-16" @default.
- W52003657 title "Functional recovery after rhesus monkey spinal cord injury by transplantation of bone marrow mesenchymal-stem cell-derived neurons." @default.
- W52003657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16232330" @default.
- W52003657 hasPublicationYear "2005" @default.
- W52003657 type Work @default.
- W52003657 sameAs 52003657 @default.
- W52003657 citedByCount "17" @default.
- W52003657 countsByYear W520036572014 @default.
- W52003657 countsByYear W520036572015 @default.
- W52003657 countsByYear W520036572016 @default.
- W52003657 countsByYear W520036572017 @default.
- W52003657 countsByYear W520036572018 @default.
- W52003657 crossrefType "journal-article" @default.
- W52003657 hasAuthorship W52003657A5003551515 @default.
- W52003657 hasAuthorship W52003657A5019009434 @default.
- W52003657 hasAuthorship W52003657A5032221349 @default.
- W52003657 hasAuthorship W52003657A5036522440 @default.
- W52003657 hasAuthorship W52003657A5050789305 @default.
- W52003657 hasAuthorship W52003657A5069736511 @default.
- W52003657 hasAuthorship W52003657A5075596275 @default.
- W52003657 hasConcept C105702510 @default.
- W52003657 hasConcept C118552586 @default.
- W52003657 hasConcept C125473707 @default.
- W52003657 hasConcept C141071460 @default.
- W52003657 hasConcept C142724271 @default.
- W52003657 hasConcept C181199279 @default.
- W52003657 hasConcept C198826908 @default.
- W52003657 hasConcept C204232928 @default.
- W52003657 hasConcept C2776378061 @default.
- W52003657 hasConcept C2778334475 @default.
- W52003657 hasConcept C2779384463 @default.
- W52003657 hasConcept C2780723820 @default.
- W52003657 hasConcept C2780775167 @default.
- W52003657 hasConcept C2911091166 @default.
- W52003657 hasConcept C55493867 @default.
- W52003657 hasConcept C71924100 @default.
- W52003657 hasConcept C86803240 @default.
- W52003657 hasConcept C9497952 @default.
- W52003657 hasConceptScore W52003657C105702510 @default.
- W52003657 hasConceptScore W52003657C118552586 @default.
- W52003657 hasConceptScore W52003657C125473707 @default.
- W52003657 hasConceptScore W52003657C141071460 @default.
- W52003657 hasConceptScore W52003657C142724271 @default.
- W52003657 hasConceptScore W52003657C181199279 @default.
- W52003657 hasConceptScore W52003657C198826908 @default.
- W52003657 hasConceptScore W52003657C204232928 @default.
- W52003657 hasConceptScore W52003657C2776378061 @default.
- W52003657 hasConceptScore W52003657C2778334475 @default.
- W52003657 hasConceptScore W52003657C2779384463 @default.
- W52003657 hasConceptScore W52003657C2780723820 @default.
- W52003657 hasConceptScore W52003657C2780775167 @default.
- W52003657 hasConceptScore W52003657C2911091166 @default.
- W52003657 hasConceptScore W52003657C55493867 @default.
- W52003657 hasConceptScore W52003657C71924100 @default.
- W52003657 hasConceptScore W52003657C86803240 @default.
- W52003657 hasConceptScore W52003657C9497952 @default.
- W52003657 hasIssue "18" @default.
- W52003657 hasLocation W520036571 @default.
- W52003657 hasOpenAccess W52003657 @default.
- W52003657 hasPrimaryLocation W520036571 @default.
- W52003657 hasRelatedWork W2043377279 @default.
- W52003657 hasRelatedWork W2148045340 @default.
- W52003657 hasRelatedWork W2353921525 @default.
- W52003657 hasRelatedWork W2366450634 @default.
- W52003657 hasRelatedWork W2367629193 @default.
- W52003657 hasRelatedWork W2373178966 @default.
- W52003657 hasRelatedWork W2384813459 @default.
- W52003657 hasRelatedWork W3151110460 @default.
- W52003657 hasRelatedWork W4210776572 @default.
- W52003657 hasRelatedWork W52003657 @default.
- W52003657 hasVolume "118" @default.
- W52003657 isParatext "false" @default.
- W52003657 isRetracted "false" @default.
- W52003657 magId "52003657" @default.
- W52003657 workType "article" @default.