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- W52096194 abstract "OBJECTIVE: The purpose of this study was to determine whether combined treatment with a selective serotonin reuptake inhibitor (SSRI) and a norepinephrine reuptake inhibitor, desipramine, effectively reduces obsessive-compulsive symptoms in patients who do not respond to SSRIs. METHOD: In a double-blind study, desipramine or placebo was added for 6 or 10 weeks to the treatment of 30 patients with obsessive-compulsive disorder whose symptoms were refractory to SSRI treatment (fluvoxamine, fluoxetine, or sertraline) alone. RESULTS: There were no significant differences between the adjunctive desipramine and placebo groups in obsessive-compulsive or depressive symptoms. CONCLUSIONS: These data suggest that clomipramine's possibly superior efficacy in the treatment of obsessive-compulsive symptoms may not stem from its capacity to inhibit reuptake of norepinephrine." @default.
- W52096194 created "2016-06-24" @default.
- W52096194 date "1997-09-01" @default.
- W52096194 modified "2023-10-18" @default.
- W52096194 title "Addition of desipramine to serotonin reuptake inhibitors in treatment- resistant obsessive-compulsive disorder" @default.
- W52096194 doi "https://doi.org/10.1176/ajp.154.9.1293" @default.
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