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• W5211269 abstract "Event Abstract Back to Event Place cells' firing in the Tg2576 Alzheimer mouse model Francesca Cacucci1* 1 University College London, United Kingdom In Alzheimer's disease (AD), damage to the hippocampal formation produces a severe loss of episodic and spatial memories. There is converging evidence suggesting that, in AD, beta-amyloid accumulation induces synaptic failure. However, it remains unclear how these biochemical and physiological alterations affect the representational abilities of hippocampal neurones in vivo. Hippocampal place cells increase their firing rates in restricted areas of an environment, and the set of active cells is believed to represent the spatial organization of an environment, and form the basis for spatial memory and flexible navigation. By combining behavioural testing and place cell recording in the tg2576 mouse model of AD, I have demonstrated that transgenic mice show an age-dependent impairment in both the spatial representation at the hippocampal cell level, and in a spatial working memory task. Place cell spatial signalling is disrupted in aged but not young tg2576, compared to age-matched controls. These physiological alterations in CA1 place cells correlate with the degree of impairment on the T-maze spatial alternation task. Moreover, there is a good correlation between the burden of congophilic amyloid plaques in the hippocampus and the degree of disruption of place cells, on one hand, and the behavioural deficits, on the other. These results do not rule out the possibility that soluble amyloid, rather than compact amyloid plaques is a sufficient pathological agent to cause behavioural and network dysfunction. During the talk I will also report some of our most recent results relating to the infusion of soluble beta-amyloid species into the hippocampus of healthy rats. Conference: 41st European Brain and Behaviour Society Meeting, Rhodes Island, Greece, 13 Sep - 18 Sep, 2009. Presentation Type: Oral Presentation Topic: Symposia lectures Citation: Cacucci F (2009). Place cells' firing in the Tg2576 Alzheimer mouse model. Conference Abstract: 41st European Brain and Behaviour Society Meeting. doi: 10.3389/conf.neuro.08.2009.09.014 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 04 Jun 2009; Published Online: 04 Jun 2009. * Correspondence: Francesca Cacucci, University College London, London, United Kingdom, f.cacucci@ucl.ac.uk Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Francesca Cacucci Google Francesca Cacucci Google Scholar Francesca Cacucci PubMed Francesca Cacucci Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W5211269 title "Place cells' firing in the Tg2576 Alzheimer mouse model" @default.
• W5211269 doi "https://doi.org/10.3389/conf.neuro.08.2009.09.014" @default.
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