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- W52113204 abstract "Wehavefound that Saccharomyces cerevisuze acquires spontaneously increasing resistance to2-deoxyglucose ataveryhighfrequency. Thisfinding allows theeasyisolation ofdifferent types ofresistant strains ofinterest formetabolic studies with2-deoxyhexoses. Ontheother hand, itsounds anoteofcaution inthewidespread use of2-deoxyglucose asaselective agent fortheisolation ofyeast mutants withimpaired hexose transport or phosphorylation systems. Yeastgrowth andfermentation arestrongly inhibited by 2-deoxyglucose (deGlc) (2,3,8).Thedegree ofinhibition depends ontheintracellular concentration of2-deoxyglucose-6-phosphate (deGlc-6-P), theproduct ofphosphorylationofdeGlc(15). We previously isolated a mutantof Saccharomyces cerevisiae resistant tothetoxic effect of deGic andestablished thebiochemical basis ofthis resistance(9). Themutanthashighlevels ofa constitutive phosphatase whichprevents intracellular accumulation of deGlc-6-P. Accumulation ofthis andother deoxysugar phosphates haslethal effects notonlyinyeasts (13) butalso in other eucaryotic organisms (5)." @default.
- W52113204 created "2016-06-24" @default.
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- W52113204 date "1988-01-01" @default.
- W52113204 modified "2023-09-27" @default.
- W52113204 title "Saccharomyces cerevisiae Acquires Resistance to2-Deoxyglucose at aVeryHighFrequencyt" @default.
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- W52113204 hasPublicationYear "1988" @default.
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