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- W52161187 abstract "Patients (pts) undergoing autologous hematopoietic stem cell transplantation are at high risk for infectious complications. A retrospective analysis of 157 pts undergoing high-dose chemotherapy and autologous peripheral stem cell transplantation was conducted and the incidence and causes of infections were statistically evaluated depending on risk factors. In total, 197 therapy cycles were evaluated. The median age was 54 years. Pts had following underlying diseases: multiple myeloma (MM) (49%), non hodgkin lymphoma (NHL) (30%), germ cell tumor (GCT) (15%), Hodgkin`s disease (4%) and others (2%). The median time of neutropenia was 9 days. In 182 therapy cycles an antimicrobial therapy was necessary because of febrile events: 88 pts had fever of unknown origin (fuo), 45 pts bacteremia (30 grampositive, 15 gramnegative), 23 pts pneumonia, 16 pts a clinically documented infection and 10 pts a microbiologically documented infection. Transplantation-associated mortality was 3,8%. Median time to defervescence correlated with the duration of neutropenia (p < 0.001) and with proven infections (p < 0.001). The incidence of infection was significant more common in pts ≥ 40 years (p = 0.01) and depended on the underlying disease: MM > NHL > GCT. The median time of neutropenia was significant longer in pts with NHL than in pts with MM or GCT. In this study, pts with MM undergoing autologous peripheral HSCT have a higher risk of infectious complications despite a shorter median duration of neutropenia. This may be due to the presence of the humoral immune defect in MM." @default.
- W52161187 created "2016-06-24" @default.
- W52161187 creator A5091817179 @default.
- W52161187 date "2022-02-20" @default.
- W52161187 modified "2023-10-01" @default.
- W52161187 title "Infektiöse Komplikationen nach Hochdosischemotherapie mit autologer peripherer Stammzelltransplantation an der Klinik für Hämatologie und Onkologie der Universitätsmedizin Göttingen" @default.
- W52161187 doi "https://doi.org/10.53846/goediss-3792" @default.
- W52161187 hasPublicationYear "2022" @default.
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