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• W52202272 abstract "Abstract Parkinson's disease (PD) is an idiopathic degenerative disorder of the central nervous system commonly affecting the elderly. In PD, dopaminergic neurons in the substantia nigra of the ventral midbrain selectively degenerate causing a number of movement disorders such as shaking, rigidity, slowness of movement, bradykinesia, and others, as early symptoms and cognitive and behavioural problems associated with dementia occurring at the later stages. Currently, the dopamine (DA) precursor, levodopa (L-DOPA), and DA agonists are used to manage the early motor symptoms associated with PD, but during the later stages, these drugs become ineffective and the treatment in the long run might cause motor complications, dyskinesia, and decreased drug response and drug-induced toxicity. Monoamine oxidase inhibitors and catechol-O-methyltransferase inhibitors have also been tried but, overall, the anti-PD treatments seem to be very limited. For this reason, as an alternative independent therapeutic approach or an aid to the existing therapy, a wide range of natural substances with neuroprotective properties have been tested for their potent anti-PD activity. Amelioration of neurotoxic effects of certain anti-PD drugs by herbal treatments has also been reported. Traditional and complementary therapies also include herbal preparations subjected to be evaluated for active constituents with anti-PD activities. Plants such as Olea europaea, Hypericum perforatum, Ginkgo biloba, Mucuna pruriens, Banisteria caapi, Polygonum cuspidatum, Withania somnifera, Gynostemma pentaphyllum, Glycine max, Trifolium pretense, and Scutellaria baicalensis have been reported to possess anti-PD activities. Recently, natural compounds such as oleuropein, hyperforin, silymarin, melatonin, resveratrol, baicalin, cistanche total and phenylethanoid glycosides, ginsenoside, salvianolic acid B, salvianic acid A, astaxanthin, triptolide, genistein, biochanin A, luteolin, and others, have been evaluated in vivo for anti-PD and neuroprotective activities. Natural compounds exert their anti-PD effects by inhibiting microglial activation to protect inflammation-mediated degeneration of dopaminergic neurons and by inhibiting proinflammatory factors or superoxide generation. The present review also focuses on certain traditional herbal anti-PD treatments with traditional Chinese medicine, for example, Zhen-Wu-Tang, Bushen Huoxue Granule, Yokukansan, and others. In a nutshell, the review deals with the literature covering use of botanical-derived natural products, either as crude extracts or isolated compounds in monoherbal or polyherbal formulations, having anti-PD activity with notes on source plant, active component, experimental methodology, and ethnopharmacological relevance of anti-PD efficacy of the natural compounds." @default.
• W52202272 created "2016-06-24" @default.
• W52202272 creator A5010329370 @default.
• W52202272 creator A5081969919 @default.
• W52202272 date "2015-01-01" @default.
• W52202272 modified "2023-09-26" @default.
• W52202272 title "Possible Anti-Parkinson’s Disease Therapeutics From Nature: A Review" @default.
• W52202272 cites W1491076928 @default.
• W52202272 cites W1495483872 @default.
• W52202272 cites W1502339857 @default.
• W52202272 cites W1514721217 @default.
• W52202272 cites W1517870020 @default.
• W52202272 cites W1522051947 @default.
• W52202272 cites W1529576429 @default.
• W52202272 cites W1537761539 @default.
• W52202272 cites W1543194037 @default.
• W52202272 cites W1566136977 @default.
• W52202272 cites W1589678175 @default.
• W52202272 cites W1594373583 @default.
• W52202272 cites W1620810572 @default.
• W52202272 cites W1736815781 @default.
• W52202272 cites W1837316150 @default.
• W52202272 cites W1963841078 @default.
• W52202272 cites W1964014604 @default.
• W52202272 cites W1964455116 @default.
• W52202272 cites W1964694445 @default.
• W52202272 cites W1965311606 @default.
• W52202272 cites W1965609196 @default.
• W52202272 cites W1965877753 @default.
• W52202272 cites W1966609492 @default.
• W52202272 cites W1966886064 @default.
• W52202272 cites W1968787780 @default.
• W52202272 cites W1970878598 @default.
• W52202272 cites W1970921442 @default.
• W52202272 cites W1970930356 @default.
• W52202272 cites W1972227458 @default.
• W52202272 cites W1972305402 @default.
• W52202272 cites W1972757313 @default.
• W52202272 cites W1972805167 @default.
• W52202272 cites W1973080574 @default.
• W52202272 cites W1973100958 @default.
• W52202272 cites W1973252962 @default.
• W52202272 cites W1973455163 @default.
• W52202272 cites W1973689750 @default.
• W52202272 cites W1973791051 @default.
• W52202272 cites W1974423746 @default.
• W52202272 cites W1974654202 @default.
• W52202272 cites W1975257396 @default.
• W52202272 cites W1975619206 @default.
• W52202272 cites W1975648951 @default.
• W52202272 cites W1976219141 @default.
• W52202272 cites W1976387946 @default.
• W52202272 cites W1976799053 @default.
• W52202272 cites W1976933002 @default.
• W52202272 cites W1976983937 @default.
• W52202272 cites W1977464159 @default.
• W52202272 cites W1977598635 @default.
• W52202272 cites W1977817564 @default.
• W52202272 cites W1977981404 @default.
• W52202272 cites W1978025210 @default.
• W52202272 cites W1978047126 @default.
• W52202272 cites W1978071954 @default.
• W52202272 cites W1978961664 @default.
• W52202272 cites W1979635851 @default.
• W52202272 cites W1980011211 @default.
• W52202272 cites W1980237303 @default.
• W52202272 cites W1980644890 @default.
• W52202272 cites W1981144487 @default.
• W52202272 cites W1981788851 @default.
• W52202272 cites W1983490063 @default.
• W52202272 cites W1984247427 @default.
• W52202272 cites W1984562258 @default.
• W52202272 cites W1986201527 @default.
• W52202272 cites W1986553796 @default.
• W52202272 cites W1987176816 @default.
• W52202272 cites W1987814789 @default.
• W52202272 cites W1988617075 @default.
• W52202272 cites W1989346488 @default.
• W52202272 cites W1991158061 @default.
• W52202272 cites W1991715802 @default.
• W52202272 cites W1992123323 @default.
• W52202272 cites W1993100025 @default.
• W52202272 cites W1994985737 @default.
• W52202272 cites W1995334846 @default.
• W52202272 cites W1996492103 @default.
• W52202272 cites W1996985625 @default.
• W52202272 cites W1997105126 @default.
• W52202272 cites W1997843169 @default.
• W52202272 cites W1998171278 @default.
• W52202272 cites W1999272442 @default.
• W52202272 cites W2000067823 @default.
• W52202272 cites W2000197504 @default.
• W52202272 cites W2000337096 @default.
• W52202272 cites W2000538921 @default.
• W52202272 cites W2000877308 @default.
• W52202272 cites W2001038624 @default.
• W52202272 cites W2001468810 @default.
• W52202272 cites W2001788103 @default.
• W52202272 cites W2002703101 @default.
• W52202272 cites W2003699360 @default.

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