Matches in SemOpenAlex for { <https://semopenalex.org/work/W52207269> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W52207269 endingPage "60" @default.
- W52207269 startingPage "551" @default.
- W52207269 abstract "Intrapulmonary interleukin-1 beta (IL-1 beta) participates in the pathogenesis of acute IgG immune-complex alveolitis through a mechanism involving neutrophil recruitment. We have examined the relationship between intrapulmonary IL-1 beta and locally produced platelet-activating factor (PAF) in the development of acute alveolitis. Instillation of IgG anti-bovine albumin into the lungs of rats, followed immediately by intravenous infusion of bovine serum albumin (BSA), resulted in acute neutrophil-mediated lung injury. Development of IgG immune-complex lung injury was accompanied by three- and five-fold increases in bronchoalveolar lavage (BAL) fluid and whole lung PAF levels, respectively. Intratracheal administration of the PAF antagonists, WEB-2086 (Boehringer) or L-652,731 (Merck, Sharpe, and Dohme, Rahway, NJ), reduced pulmonary vascular leakage. Neutralization of intrapulmonary IL-1 activity with anti-IL-1 beta antibodies reduced pulmonary vascular permeability and whole lung PAF levels. Morphometric analysis and whole lung myeloperoxidase measurements revealed a differential effect between the PAF antagonists and anti-IL-1 beta with respect to pulmonary neutrophil recruitment. Intratracheal instillation of anti-IL-1 beta retarded net pulmonary neutrophil recruitment while the PAF antagonists retarded migration of neutrophils from the interstitial/vascular compartments into the alveolar compartment. Intratracheal instillation of anti-IL-1 beta plus L-652,731 resulted in reduction in lung vascular permeability and retarded net pulmonary neutrophil recruitment. No additive effect was observed. Stimulation of isolated mouse alveolar macrophages with recombinant murine IL-1 beta or IL-1 alpha resulted in rapid, dose-dependent, and cell concentration-dependent increases in PAF secretion. These data suggest that intrapulmonary IL-1 beta amplifies local PAF production and that IL-1 beta and PAF modulate different aspects of pulmonary neutrophil recruitment." @default.
- W52207269 created "2016-06-24" @default.
- W52207269 creator A5032533225 @default.
- W52207269 date "1992-09-01" @default.
- W52207269 modified "2023-09-29" @default.
- W52207269 title "Relationship between interleukin-1 beta and platelet-activating factor in the pathogenesis of acute immune complex alveolitis in the rat." @default.
- W52207269 cites W1490409409 @default.
- W52207269 cites W1513774612 @default.
- W52207269 cites W1528319719 @default.
- W52207269 cites W1555039664 @default.
- W52207269 cites W1569863959 @default.
- W52207269 cites W1576430359 @default.
- W52207269 cites W1578996543 @default.
- W52207269 cites W1587142652 @default.
- W52207269 cites W1591379573 @default.
- W52207269 cites W1850688915 @default.
- W52207269 cites W1881475207 @default.
- W52207269 cites W1921676257 @default.
- W52207269 cites W1968988918 @default.
- W52207269 cites W1977363772 @default.
- W52207269 cites W1978718653 @default.
- W52207269 cites W1991780446 @default.
- W52207269 cites W1999797629 @default.
- W52207269 cites W2007078473 @default.
- W52207269 cites W2012757704 @default.
- W52207269 cites W2056336171 @default.
- W52207269 cites W2057826744 @default.
- W52207269 cites W2057905142 @default.
- W52207269 cites W2060270186 @default.
- W52207269 cites W2072036820 @default.
- W52207269 cites W2072196714 @default.
- W52207269 cites W2084279575 @default.
- W52207269 cites W2103891004 @default.
- W52207269 cites W2107396956 @default.
- W52207269 cites W2152311269 @default.
- W52207269 cites W2316777328 @default.
- W52207269 cites W2399977173 @default.
- W52207269 cites W273469803 @default.
- W52207269 cites W81337151 @default.
- W52207269 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1886684" @default.
- W52207269 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1519663" @default.
- W52207269 hasPublicationYear "1992" @default.
- W52207269 type Work @default.
- W52207269 sameAs 52207269 @default.
- W52207269 citedByCount "8" @default.
- W52207269 countsByYear W522072692019 @default.
- W52207269 crossrefType "journal-article" @default.
- W52207269 hasAuthorship W52207269A5032533225 @default.
- W52207269 hasConcept C113045295 @default.
- W52207269 hasConcept C126322002 @default.
- W52207269 hasConcept C142724271 @default.
- W52207269 hasConcept C203014093 @default.
- W52207269 hasConcept C2777714996 @default.
- W52207269 hasConcept C2777961210 @default.
- W52207269 hasConcept C2778474638 @default.
- W52207269 hasConcept C2779020240 @default.
- W52207269 hasConcept C2780942790 @default.
- W52207269 hasConcept C71924100 @default.
- W52207269 hasConcept C8891405 @default.
- W52207269 hasConceptScore W52207269C113045295 @default.
- W52207269 hasConceptScore W52207269C126322002 @default.
- W52207269 hasConceptScore W52207269C142724271 @default.
- W52207269 hasConceptScore W52207269C203014093 @default.
- W52207269 hasConceptScore W52207269C2777714996 @default.
- W52207269 hasConceptScore W52207269C2777961210 @default.
- W52207269 hasConceptScore W52207269C2778474638 @default.
- W52207269 hasConceptScore W52207269C2779020240 @default.
- W52207269 hasConceptScore W52207269C2780942790 @default.
- W52207269 hasConceptScore W52207269C71924100 @default.
- W52207269 hasConceptScore W52207269C8891405 @default.
- W52207269 hasIssue "3" @default.
- W52207269 hasLocation W522072691 @default.
- W52207269 hasOpenAccess W52207269 @default.
- W52207269 hasPrimaryLocation W522072691 @default.
- W52207269 hasRelatedWork W1654101383 @default.
- W52207269 hasRelatedWork W1937813991 @default.
- W52207269 hasRelatedWork W2033875947 @default.
- W52207269 hasRelatedWork W2362365632 @default.
- W52207269 hasRelatedWork W2367406969 @default.
- W52207269 hasRelatedWork W2371274184 @default.
- W52207269 hasRelatedWork W2379930273 @default.
- W52207269 hasRelatedWork W2386252553 @default.
- W52207269 hasRelatedWork W52207269 @default.
- W52207269 hasRelatedWork W81337151 @default.
- W52207269 hasVolume "141" @default.
- W52207269 isParatext "false" @default.
- W52207269 isRetracted "false" @default.
- W52207269 magId "52207269" @default.
- W52207269 workType "article" @default.