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- W52361731 abstract "Abstract Characterization of the molecular structure and function of dopamine D 1 and D 2 receptors may be enhanced by new molecular probes such as stereoisomeric, photoaffinity, affinity, fluorescent and biotin labeled probes with a high affinity and selectivity for D 1 and D 2 receptor types. Our results with D 2 agonist aporphines [2-F-NPA and 2-OH-NPA], stereoselective D 1 benzazepine agonists [R(+)Br-APB], photoaffinity probes [(±)[ 125 I]-I-MAB] and novel alkylating derivatives of D 1 and D 2 selective dopamine agonists and antagonists were evaluated for affinity in radioreceptor assays. Biological activities of compounds with or without alkylating moieties were compared by their ability to block behavioral actions of apomorphine, over time. Several fluorescent and biotin labeled probes for D 1 and D 2 receptors also were developed, based on the D 1 antagonist, SKF-83566, the D 2 agonist PPHT and D 2 antagonist spiperone." @default.
- W52361731 created "2016-06-24" @default.
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- W52361731 date "1992-01-01" @default.
- W52361731 modified "2023-09-23" @default.
- W52361731 title "Stereoisomeric, Photoaffinity, Affinity and Fluorescent Probes for Characterization of Dopamine D1 and D2 Receptors" @default.
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- W52361731 doi "https://doi.org/10.1016/b978-0-444-88931-7.50016-5" @default.
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