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• W52361882 abstract "We have used confocal immunofluorescence microscopy and immunogold electron microscopy to localize tumor necrosis factor (TNF) receptors in cultured human umbilical vein endothelial cells. The 75-kd receptor is largely expressed on the cell surface and undergoes endocytosis and transport to lycosomes through coated pits and coated vesicles. TNF may accelerate receptor clustering and internalization. The 55-kd receptor is expressed at much lower levels on the cell surface than the 75-kd receptor but is more abundant overall. It is predominantly localized to the Golgi apparatus and, to a lesser extent, cytoplasmic vacuoles. The cellular distribution of the 55-kd receptor is largely unaffected by TNF. These results have implications for TNF-mediated endothelial cell activation and for interactions between 75- and 55-kd TNF receptors." @default.
• W52361882 created "2016-06-24" @default.
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• W52361882 date "1995-01-01" @default.
• W52361882 modified "2023-09-23" @default.
• W52361882 title "Disparate localization of 55-kd and 75-kd tumor necrosis factor receptors in human endothelial cells." @default.
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• W52361882 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1870772" @default.
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