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• W52387617 abstract "Research Article1 September 1986free access Abelson transformed fibroblasts lacking the EGF receptor are not tumourigenic in nude mice. A. Gebhardt A. Gebhardt Search for more papers by this author J.C. Bell J.C. Bell Search for more papers by this author J.G. Foulkes J.G. Foulkes Search for more papers by this author A. Gebhardt A. Gebhardt Search for more papers by this author J.C. Bell J.C. Bell Search for more papers by this author J.G. Foulkes J.G. Foulkes Search for more papers by this author Author Information A. Gebhardt, J.C. Bell and J.G. Foulkes The EMBO Journal (1986)5:2191-2195https://doi.org/10.1002/j.1460-2075.1986.tb04483.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Cells transformed by the v-abl-oncogene produce large amounts of the tumour growth factor alpha TGF. alpha TGF is homologous to the epidermal growth factor (EGF) and stimulates cell growth via the EGF receptor pathway. To separate metabolic events in the v-abl-transformed cells mediated by alpha TGF as opposed to the v-abl-encoded protein-tyrosine kinase, we have employed the Swiss 3T3 variant cell line NR6 which lacks a functional EGF receptor. v-abl was found to transform efficiently NR6 cells in vitro. These transformed NR6 cells displayed a variety of in vitro properties which were indistinguishable from transformed wild-type fibroblast lines. However, in contrast to the wild-type lines, v-abl-transformed NR6 cells failed to form tumours when injected into athymic nude mice. These results imply an important function for alpha TGF and the EGF receptor in the establishment of the v-abl-induced fibrosarcomas. Previous ArticleNext Article Volume 5Issue 91 September 1986In this issue RelatedDetailsLoading ..." @default.
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• W52387617 title "Abelson transformed fibroblasts lacking the EGF receptor are not tumourigenic in nude mice." @default.
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• W52387617 doi "https://doi.org/10.1002/j.1460-2075.1986.tb04483.x" @default.
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