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- W52393495 abstract "HOZOT cell lines are one type of the regulatory T cells (Treg) established from human umbilical cord blood (UCB) without cytokines. These HOZOT cells have multi-functional activities, not only suppressor but also cytotoxic activity. In this study, we have examined another novel function of HOZOT in immune system. Cord blood naive CD4+ T cells as responder cells were stimulated with dendritic cells (DC) or plate coated anti-CD3 antibody (anti-CD3 Ab) in the presence of HOZOT-4. The DC-induced proliferation of naive CD4+ T cells derived from UCB was inhibited by the addition of HOZOT-4. Whereas, anti-CD3 Ab-induced proliferation was promoted by the same treatment. Anti-CD3 Ab -cultures have produced IFN-γ, not IL-4. Opposing effects of HOZOT-4 were unique because naturally occurring Treg inhibited both DC- and anti-CD3 Ab-induced stimulations. Kinetics study showed that cell division was first detected at day 3 and increased later on. IL-2 was not involved in the mechanism of helper activity of HOZOT-4 because no IL-2 was detected in the anti-CD3 Ab-induced coculture system and blocking antibodies for IL-2 and IL-2R did not affect helper activity. Moreover, this helper activity could not be inhibited with blocking reagents for costimulatory molecule of CD28/B7. This helper activity exerted by HOZOT may be mediated through a novel costimulatory pathway." @default.
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- W52393495 date "2008-03-01" @default.
- W52393495 modified "2023-09-27" @default.
- W52393495 title "HOZOT, a novel type of human regulatory T cell lines, showed opposing activities, helper and suppressor, depending on the stimulations of dendritic cells or anti‐CD3 antibody" @default.
- W52393495 doi "https://doi.org/10.1096/fasebj.22.1_supplement.848.2" @default.
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