FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W52417785> ?p ?o ?g. }

• W52417785 endingPage "425" @default.
• W52417785 startingPage "420" @default.
• W52417785 abstract "For more than 30 years statins have been successfully used in patients with hypercholesterolemia and cardiovascular diseases. Recently, there is a growing body of evidence, that statins exert effects by much exceeding the effect of cholesterol level decrease. Inhibition of earlier stages of cholesterol biosynthesis pathway (not influencing the very cholesterol level) results in blocking the intermediate metabolite synthesis; isoprenoids (farnesyl phosphate and geranyl phosphate), which play a regulatory function in cells. Statins have antiatherosclerotic, antiinflammatory, antioxidant, immunomodulatory and antithrombotic effects. It applies equally to diseases of chronic inflammation type, as to those, where bone metabolism is disturbed. It is well known that statins decrease bone fracture risk; through bone formation intensification, and inhibition of bone tissue resorption. Slowing down the atherosclerosis progression is a very important effect, considering that in rheumatoid arthritis (RA) and in systemic lupus erythematosus (SLE) we are dealing with premature and rapid progression of atherosclerotic lesions. In this paper statins pathways of action in rheumatic diseases (including pleiotropic effects), and their potential use in rheumatology have been discussed. Though there is lack of reliable data enabling statins introduction to standard complementary therapy in rheumatic diseases, the results however of completed studies allow concluding of their utility. The statins that were most frequently evaluated in clinical studies were simvastatin and atorvastatin. Studies on statins have been performed in RA, SLE, osteoporosis and systemic vasculotos." @default.
• W52417785 created "2016-06-24" @default.
• W52417785 creator A5017322068 @default.
• W52417785 creator A5062647444 @default.
• W52417785 date "2007-09-01" @default.
• W52417785 modified "2023-09-25" @default.
• W52417785 title "Statins – are they potentially useful in rheumatology?" @default.
• W52417785 cites W1537398036 @default.
• W52417785 cites W1969297395 @default.
• W52417785 cites W1970106273 @default.
• W52417785 cites W1970189800 @default.
• W52417785 cites W1989528832 @default.
• W52417785 cites W1990264130 @default.
• W52417785 cites W2003307830 @default.
• W52417785 cites W2029127038 @default.
• W52417785 cites W2031010510 @default.
• W52417785 cites W2032485049 @default.
• W52417785 cites W2042657101 @default.
• W52417785 cites W2044979143 @default.
• W52417785 cites W2068898353 @default.
• W52417785 cites W2085441279 @default.
• W52417785 cites W2095200825 @default.
• W52417785 cites W2097576960 @default.
• W52417785 cites W2098149082 @default.
• W52417785 cites W2108985466 @default.
• W52417785 cites W2131275408 @default.
• W52417785 cites W2135590375 @default.
• W52417785 cites W2138968874 @default.
• W52417785 cites W2153390391 @default.
• W52417785 cites W2157253583 @default.
• W52417785 cites W2160427887 @default.
• W52417785 cites W2169537677 @default.
• W52417785 cites W2246854160 @default.
• W52417785 cites W2324841714 @default.
• W52417785 doi "https://doi.org/10.20452/pamw.206" @default.
• W52417785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18062565" @default.
• W52417785 hasPublicationYear "2007" @default.
• W52417785 type Work @default.
• W52417785 sameAs 52417785 @default.
• W52417785 citedByCount "6" @default.
• W52417785 countsByYear W524177852012 @default.
• W52417785 countsByYear W524177852013 @default.
• W52417785 countsByYear W524177852014 @default.
• W52417785 countsByYear W524177852015 @default.
• W52417785 countsByYear W524177852016 @default.
• W52417785 crossrefType "journal-article" @default.
• W52417785 hasAuthorship W52417785A5017322068 @default.
• W52417785 hasAuthorship W52417785A5062647444 @default.
• W52417785 hasBestOaLocation W524177852 @default.
• W52417785 hasConcept C126322002 @default.
• W52417785 hasConcept C170033053 @default.
• W52417785 hasConcept C198451711 @default.
• W52417785 hasConcept C2776329913 @default.
• W52417785 hasConcept C2776541429 @default.
• W52417785 hasConcept C2776839432 @default.
• W52417785 hasConcept C2776914184 @default.
• W52417785 hasConcept C2777015399 @default.
• W52417785 hasConcept C2777251235 @default.
• W52417785 hasConcept C2777482532 @default.
• W52417785 hasConcept C2777575956 @default.
• W52417785 hasConcept C2778163477 @default.
• W52417785 hasConcept C673006 @default.
• W52417785 hasConcept C71924100 @default.
• W52417785 hasConcept C98274493 @default.
• W52417785 hasConceptScore W52417785C126322002 @default.
• W52417785 hasConceptScore W52417785C170033053 @default.
• W52417785 hasConceptScore W52417785C198451711 @default.
• W52417785 hasConceptScore W52417785C2776329913 @default.
• W52417785 hasConceptScore W52417785C2776541429 @default.
• W52417785 hasConceptScore W52417785C2776839432 @default.
• W52417785 hasConceptScore W52417785C2776914184 @default.
• W52417785 hasConceptScore W52417785C2777015399 @default.
• W52417785 hasConceptScore W52417785C2777251235 @default.
• W52417785 hasConceptScore W52417785C2777482532 @default.
• W52417785 hasConceptScore W52417785C2777575956 @default.
• W52417785 hasConceptScore W52417785C2778163477 @default.
• W52417785 hasConceptScore W52417785C673006 @default.
• W52417785 hasConceptScore W52417785C71924100 @default.
• W52417785 hasConceptScore W52417785C98274493 @default.
• W52417785 hasIssue "9" @default.
• W52417785 hasLocation W524177851 @default.
• W52417785 hasLocation W524177852 @default.
• W52417785 hasLocation W524177853 @default.
• W52417785 hasLocation W524177854 @default.
• W52417785 hasOpenAccess W52417785 @default.
• W52417785 hasPrimaryLocation W524177851 @default.
• W52417785 hasRelatedWork W1581747141 @default.
• W52417785 hasRelatedWork W2023120740 @default.
• W52417785 hasRelatedWork W2038338711 @default.
• W52417785 hasRelatedWork W2038387969 @default.
• W52417785 hasRelatedWork W2038690234 @default.
• W52417785 hasRelatedWork W2096275148 @default.
• W52417785 hasRelatedWork W2128840214 @default.
• W52417785 hasRelatedWork W2341519648 @default.
• W52417785 hasRelatedWork W2412105987 @default.
• W52417785 hasRelatedWork W2479749263 @default.
• W52417785 hasVolume "117" @default.
• W52417785 isParatext "false" @default.

• next