Matches in SemOpenAlex for { <https://semopenalex.org/work/W52430955> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W52430955 endingPage "4" @default.
- W52430955 startingPage "1861" @default.
- W52430955 abstract "Two personally observed cases of severe agranulocytosis within 3 months, one of them fatal, could be attributed to the new dibenzodiazepine derivative Clozapine (Leponex). Clozapine, a very effective neuroleptic for the treatment of acute and chronic schizophrenia, has been found before to induce agranulocytosis of the metabolic type, as phenothiazines are known to do. An inquiry in al Swiss medical departments and mental hospitals revealed a total of 20 cases of Clozapine induced agranulocytosis in some 50% of institutions responding. 9 of these were observed in Eastern Switzerland. This time-space clustering recalls the finnish epidemic of 1975 in Southern Finland. Possible explanations for this phenomenon are discussed. Calculations of the incidence suggest a higher rate of agranulocytosis induced by Clozapine than has been assumed for the phenothiazines. Clozapine should therefore be restricted to schizophrenic patients and initially (6 weeks) be given only on a stationary basis under regular blood controls." @default.
- W52430955 created "2016-06-24" @default.
- W52430955 creator A5008278465 @default.
- W52430955 creator A5011771316 @default.
- W52430955 creator A5030934973 @default.
- W52430955 creator A5050143407 @default.
- W52430955 creator A5051194294 @default.
- W52430955 creator A5055873224 @default.
- W52430955 creator A5091188675 @default.
- W52430955 date "1977-12-10" @default.
- W52430955 modified "2023-09-23" @default.
- W52430955 title "[Frequent cases of agranulocytosis due to clozapin (leponex) in eastern Switzerland]." @default.
- W52430955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/929152" @default.
- W52430955 hasPublicationYear "1977" @default.
- W52430955 type Work @default.
- W52430955 sameAs 52430955 @default.
- W52430955 citedByCount "6" @default.
- W52430955 crossrefType "journal-article" @default.
- W52430955 hasAuthorship W52430955A5008278465 @default.
- W52430955 hasAuthorship W52430955A5011771316 @default.
- W52430955 hasAuthorship W52430955A5030934973 @default.
- W52430955 hasAuthorship W52430955A5050143407 @default.
- W52430955 hasAuthorship W52430955A5051194294 @default.
- W52430955 hasAuthorship W52430955A5055873224 @default.
- W52430955 hasAuthorship W52430955A5091188675 @default.
- W52430955 hasConcept C118552586 @default.
- W52430955 hasConcept C120665830 @default.
- W52430955 hasConcept C121332964 @default.
- W52430955 hasConcept C187212893 @default.
- W52430955 hasConcept C2776412080 @default.
- W52430955 hasConcept C2780864610 @default.
- W52430955 hasConcept C61511704 @default.
- W52430955 hasConcept C71924100 @default.
- W52430955 hasConceptScore W52430955C118552586 @default.
- W52430955 hasConceptScore W52430955C120665830 @default.
- W52430955 hasConceptScore W52430955C121332964 @default.
- W52430955 hasConceptScore W52430955C187212893 @default.
- W52430955 hasConceptScore W52430955C2776412080 @default.
- W52430955 hasConceptScore W52430955C2780864610 @default.
- W52430955 hasConceptScore W52430955C61511704 @default.
- W52430955 hasConceptScore W52430955C71924100 @default.
- W52430955 hasIssue "49" @default.
- W52430955 hasLocation W524309551 @default.
- W52430955 hasOpenAccess W52430955 @default.
- W52430955 hasPrimaryLocation W524309551 @default.
- W52430955 hasRelatedWork W11075747 @default.
- W52430955 hasRelatedWork W1551052972 @default.
- W52430955 hasRelatedWork W2016602126 @default.
- W52430955 hasRelatedWork W2274792035 @default.
- W52430955 hasRelatedWork W2372091399 @default.
- W52430955 hasRelatedWork W2478399397 @default.
- W52430955 hasRelatedWork W3080081859 @default.
- W52430955 hasRelatedWork W3085453418 @default.
- W52430955 hasRelatedWork W4205148551 @default.
- W52430955 hasRelatedWork W4245148164 @default.
- W52430955 hasVolume "107" @default.
- W52430955 isParatext "false" @default.
- W52430955 isRetracted "false" @default.
- W52430955 magId "52430955" @default.
- W52430955 workType "article" @default.