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- W52437997 abstract "Publisher Summary In the presence of tubocurarine, aminopyridine enhances the rundown of trains of endplate potentials. It is possible that this effect may reflect a prejunctional action of tubocurarine, acting to reduce transmitter mobilization. This chapter discusses a study to investigate increased tetanic fade produced by 3,4-diaminopyridine (DAP) in the presence of neuromuscular blocking agents. This study examined the ability of DAP to enhance the fade of tetanic tension (50 Hz for 1.9 s) produced by a range of nondepolarizing neuromuscular blocking agents in the isolated rat phrenic nerve–hemidiaphragm preparation. DAP alone (50 μM) increased twitch and tetanic tension by 256 ± 17% and 21 ± 7%, respectively, and caused only 2.5 ± 0.9% tetanic fade. The concentrations of neuromuscular blockers that produced 26 ± 8.6% tetanic fade under equilibrium conditions were chosen and DAP (50 μM) was added." @default.
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- W52437997 date "1982-01-01" @default.
- W52437997 modified "2023-09-27" @default.
- W52437997 title "Increased Tetanic Fade Produced by 3,4-Diaminopyridine in the Presence of Neuromuscular Blocking Agents" @default.
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