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• W5253051 startingPage "215" @default.
• W5253051 abstract "Heart disease is a leading cause of death and disability in the Western world and a major factor in rising health care costs. Despite great efforts and remarkable advances made over the past years, the molecular basis for heart development and the evolution of acquired heart disease are still poorly defined (Chien 2000; Srivastava and Olson 2000). Approximately 10% of spontaneous abortions and stillborns are caused by severe cardiac malformations (Hoffman 1995a, 1995b). In addition, congenital heart defects including aberrant cardiac outflow septation, valve formation, aortic stenosis or hypoplastic left ventricle are prevalent with a frequency of 8 cases in 1000 births. Understanding cardiac development in cellular and molecular terms, therefore, is of major clinical relevance. Key genes in cardiac development are also important components of regulatory circuits in the adult heart (Chien 2000). For example, cardiacrestricted transcription factors such as Nkx2.5 and GATA4 have been implicated, both in cardiac development and under pathophysiological conditions, in the adult heart. GATA4 and its interacting protein partner NFATc have been identified as important components of a signalling pathway involved in generating cardiac hypertrophy (Molkentin et al. 1998). Point mutations in human NKX2.5 (CSX) have been found to cause multiple congenital malformations including atrial and ventricular septal defects, Ebstein’s anomaly and other tricuspid valve abnormalities. NKX2.5 mutations are also responsible for familial ventricular arrhythmias in the adult (Schott et al. 1998; Benson et al. 1999). Thus, understanding cardiac development at the molecular level will result in the identification of genetic networks, which are active in various pathophysiological processes in the adult heart as well. For further reading on cardiac development the reader is referred to other recent reviews on these topics (Chen and Fishman 2000; Lough and Sugi 2000; Rosenthal and Xavier-Neto 2000; Srivastava and Olson 2000).KeywordsPrimitive StreakHeart FieldHeart FormationCardiac MesodermTubular HeartThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
• W5253051 created "2016-06-24" @default.
• W5253051 creator A5028137643 @default.
• W5253051 creator A5030688685 @default.
• W5253051 creator A5031173643 @default.
• W5253051 date "2002-01-01" @default.
• W5253051 modified "2023-10-16" @default.
• W5253051 title "Molecular Characterization of Early Cardiac Development" @default.
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