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- W5261185 abstract "Siberian hamsters kept in long photoperiods (16 h light/day) at 10 degrees C do not display torpor when provided with food ad libitum but do reduce their body temperatures (Tb) from 37 degrees C to as low as 15 degrees C for several hours each day in response to food restriction. Female hamsters maintained in a long photoperiod and fed ad libitum were injected with 2-deoxy-D-glucose (2-DG), a glucose analogue that reduces cellular glucose oxidation, or mercaptoacetate (MA), a drug that disrupts fatty acid oxidation. Dosages of 2-DG in excess of 1,500 mg/kg body mass reliably induced torpor with latencies of approximately 50 min from time of injection to a decrease in Tb below 30 degrees C; 79% of females displayed torpor at a dosage of 2,500 mg/kg. MA was uniformly ineffective in inducing torpor and did not increase incidence of torpor when combined with 2-DG treatment or food restriction. Decreased availability of glucose may be the major metabolic signal for inducing torpor in Siberian hamsters; availability of fatty acids appears to play little if any role in regulating this behavior." @default.
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- W5261185 date "1994-08-01" @default.
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- W5261185 title "Reduced glucose availability induces torpor in Siberian hamsters" @default.
- W5261185 doi "https://doi.org/10.1152/ajpregu.1994.267.2.r496" @default.
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