FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W52676535> ?p ?o ?g. }

• W52676535 endingPage "33" @default.
• W52676535 startingPage "426" @default.
• W52676535 abstract "Olanzapine is a second generation antipsychotic of thienobenzodiazepin group, which is used in the treatment of schizophrenia, bipolar disorder, and others, mainly psychiatric. Its multireceptor action (antagonism to dopaminergic D1, D2, D4, serotoninergic 5-HT2A, 5-HT2C, histaminergic H1, cholinergic M1-5, and a1--adrenergic receptors) results in multiple clinical symptoms in the course of acute poisoning.Evaluation of incidence and intensity of clinical symptoms in patients with of acute olanzapine intoxication. The pathophysiological mechanisms of particular symptoms are also described.26 patients (mean age 37.7 +/- 15.3 years) hospitalized in 2005-2008 in toxicological centers in Krakow and Gdansk because of acute olanzapine poisoning (all patients had the toxic serum level of olanzapine above 100 ng/mL). The study group consisted of 11 men (29.3 +/- 8.5 years) and 13 women (44.9 +/- 16.4 years); 1 man and 1 woman were poisoned twice.Prospective analysis (using descriptive statistics) of data taken from medical anamnesis and results of physical examination, considering the following ones: consciousness disturbances (Glasgow Coma Scale, Matthew's scale, qualitative disturbances), vital signs (arterial blood pressure, heart rate, breathing rate, temperature), neurological findings (muscular tension, tendon reflexes, extrapyramidal symptoms, pupils) and others (oral and bronchial secretion, Poisoning Severity Score).The mean dose of ingested olanzapine in the study group was 352.5 +/- 220.0 mg, while the mean time since ingestion to hospital admission was 4.4 +/- 3.5 h. The half of the patients took other medicines together with olanzapine, and 23% consumed alcohol, as well. The following intensity of quantitative consciousness disturbances according to Matthew's scale were observed: grade 0 - 8%, I - 15%, II - 23%, III - 50%, and IV - 4%. The minimal and maximal values of blood pressure were: 102/63 +/- 16/14 and 163/ 97 +/- 27/18 mmHg, respectively; heart rate: 77 +/- 15 and 138 +/- 22 beats/min; temperature: 36.3 +/- 0.5 and 37.9 +/- 0.8 degrees C; breathing rate in non-intubated patients: 14 +/- 2 and 22 +/- 7 breaths/min. The mean duration of consciousness disturbances, endotracheal intubation and mechanical ventilation were: 44.9 +/- 31.3; 22.0 +/- 33.3 and 7.0 +/- 25.9 h, respectively. The study revealed tachycardia (85%), psychomotor agitation (81%), hypertension (73%), miosis (65%), and coma (54%) as the most common symptoms of poisoning. The hospitalization of poisoned patients lasted on average 5.7 +/- 3.6 days and the half of them were poisoned severely (PSS 3).In the course of acute olanzapine poisoning: (1) the prevailing symptoms come from circulatory and central nervous systems; (2) some symptoms are mutually opposed, eg.: coma - psychomotor agitation, hypertension - hypotension, tachycardia - bradycardia, hyperthermia - hypothermia, miosis - mydriasis; (3) rarely consciousness disturbances may persist for up to 6 days after olanzapine overdose; (4) the course of poisoning can be severe, sometimes complicated, but fatal outcomes are rare." @default.
• W52676535 created "2016-06-24" @default.
• W52676535 creator A5005069233 @default.
• W52676535 creator A5039017649 @default.
• W52676535 creator A5070591512 @default.
• W52676535 creator A5083932389 @default.
• W52676535 date "2011-01-01" @default.
• W52676535 modified "2023-09-23" @default.
• W52676535 title "[The clinical picture of acute olanzapine poisonings]." @default.
• W52676535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22010430" @default.
• W52676535 hasPublicationYear "2011" @default.
• W52676535 type Work @default.
• W52676535 sameAs 52676535 @default.
• W52676535 citedByCount "3" @default.
• W52676535 countsByYear W526765352015 @default.
• W52676535 countsByYear W526765352017 @default.
• W52676535 countsByYear W526765352018 @default.
• W52676535 crossrefType "journal-article" @default.
• W52676535 hasAuthorship W52676535A5005069233 @default.
• W52676535 hasAuthorship W52676535A5039017649 @default.
• W52676535 hasAuthorship W52676535A5070591512 @default.
• W52676535 hasAuthorship W52676535A5083932389 @default.
• W52676535 hasConcept C118552586 @default.
• W52676535 hasConcept C126322002 @default.
• W52676535 hasConcept C17624336 @default.
• W52676535 hasConcept C2776412080 @default.
• W52676535 hasConcept C2776619155 @default.
• W52676535 hasConcept C2780494398 @default.
• W52676535 hasConcept C2780616385 @default.
• W52676535 hasConcept C42219234 @default.
• W52676535 hasConcept C71924100 @default.
• W52676535 hasConceptScore W52676535C118552586 @default.
• W52676535 hasConceptScore W52676535C126322002 @default.
• W52676535 hasConceptScore W52676535C17624336 @default.
• W52676535 hasConceptScore W52676535C2776412080 @default.
• W52676535 hasConceptScore W52676535C2776619155 @default.
• W52676535 hasConceptScore W52676535C2780494398 @default.
• W52676535 hasConceptScore W52676535C2780616385 @default.
• W52676535 hasConceptScore W52676535C42219234 @default.
• W52676535 hasConceptScore W52676535C71924100 @default.
• W52676535 hasIssue "8" @default.
• W52676535 hasLocation W526765351 @default.
• W52676535 hasOpenAccess W52676535 @default.
• W52676535 hasPrimaryLocation W526765351 @default.
• W52676535 hasRelatedWork W1787454655 @default.
• W52676535 hasRelatedWork W1980492720 @default.
• W52676535 hasRelatedWork W1984981206 @default.
• W52676535 hasRelatedWork W1995382345 @default.
• W52676535 hasRelatedWork W2019086812 @default.
• W52676535 hasRelatedWork W2096138322 @default.
• W52676535 hasRelatedWork W2122623067 @default.
• W52676535 hasRelatedWork W2336697896 @default.
• W52676535 hasRelatedWork W2917524362 @default.
• W52676535 hasRelatedWork W52676535 @default.
• W52676535 hasVolume "68" @default.
• W52676535 isParatext "false" @default.
• W52676535 isRetracted "false" @default.
• W52676535 magId "52676535" @default.
• W52676535 workType "article" @default.