Matches in SemOpenAlex for { <https://semopenalex.org/work/W52719346> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W52719346 endingPage "393" @default.
- W52719346 startingPage "383" @default.
- W52719346 abstract "Prostate cancer is the most common male cancer in the United States. Research on the mechanisms of prostate cancer progression has been limited by the lack of suitable in vitro systems. A hurdle in understanding the molecular genetic changes in prostate cancer has been the difficulty in establishing premalignant lesions and primary prostate tumors as in vitro cell cultures. Primary prostate epithelial cells grow for a finite life span and then senesce. Immortalization is defined by continuous growth of otherwise senescing cells and is believed to represent an early stage in tumor progression. To examine these early stages, we and others have developed in vitro models of prostate epithelial cell immortalization. Methods are described for the processing of primary human prostate biopsy samples and the generation of human prostate epithelial (HPE) cells in serum-free conditions. Retrovirus containing human telomerase reverse transcriptase (hTERT) is used for the immortalization of primary HPE cells, and the methods for the characterization of HPE cell lines are discussed. These in vitro prostate cell culture models are useful for the study of prostate normal and cancer stem cells, are critical for defining the mechanisms of prostate cancer progression and for testing preventive and therapeutic regimens." @default.
- W52719346 created "2016-06-24" @default.
- W52719346 creator A5087872496 @default.
- W52719346 date "2012-10-11" @default.
- W52719346 modified "2023-10-17" @default.
- W52719346 title "Human Prostate Epithelial Cell Cultures" @default.
- W52719346 cites W122817384 @default.
- W52719346 cites W1930929720 @default.
- W52719346 cites W1965734230 @default.
- W52719346 cites W2003647591 @default.
- W52719346 cites W2022988395 @default.
- W52719346 cites W2039169692 @default.
- W52719346 cites W2046577989 @default.
- W52719346 cites W2049859586 @default.
- W52719346 cites W2064409033 @default.
- W52719346 cites W2091569641 @default.
- W52719346 cites W2118933841 @default.
- W52719346 cites W2122147062 @default.
- W52719346 cites W2126913564 @default.
- W52719346 cites W2134959033 @default.
- W52719346 cites W2153382986 @default.
- W52719346 cites W2159264387 @default.
- W52719346 cites W2175247758 @default.
- W52719346 cites W2329207493 @default.
- W52719346 doi "https://doi.org/10.1007/978-1-62703-128-8_24" @default.
- W52719346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23179845" @default.
- W52719346 hasPublicationYear "2012" @default.
- W52719346 type Work @default.
- W52719346 sameAs 52719346 @default.
- W52719346 citedByCount "5" @default.
- W52719346 countsByYear W527193462013 @default.
- W52719346 countsByYear W527193462017 @default.
- W52719346 countsByYear W527193462019 @default.
- W52719346 crossrefType "book-chapter" @default.
- W52719346 hasAuthorship W52719346A5087872496 @default.
- W52719346 hasConcept C104317684 @default.
- W52719346 hasConcept C121608353 @default.
- W52719346 hasConcept C125593758 @default.
- W52719346 hasConcept C126322002 @default.
- W52719346 hasConcept C142724271 @default.
- W52719346 hasConcept C202751555 @default.
- W52719346 hasConcept C2776235491 @default.
- W52719346 hasConcept C2780192828 @default.
- W52719346 hasConcept C502942594 @default.
- W52719346 hasConcept C54355233 @default.
- W52719346 hasConcept C71924100 @default.
- W52719346 hasConcept C81885089 @default.
- W52719346 hasConcept C86803240 @default.
- W52719346 hasConcept C87874733 @default.
- W52719346 hasConcept C94581717 @default.
- W52719346 hasConceptScore W52719346C104317684 @default.
- W52719346 hasConceptScore W52719346C121608353 @default.
- W52719346 hasConceptScore W52719346C125593758 @default.
- W52719346 hasConceptScore W52719346C126322002 @default.
- W52719346 hasConceptScore W52719346C142724271 @default.
- W52719346 hasConceptScore W52719346C202751555 @default.
- W52719346 hasConceptScore W52719346C2776235491 @default.
- W52719346 hasConceptScore W52719346C2780192828 @default.
- W52719346 hasConceptScore W52719346C502942594 @default.
- W52719346 hasConceptScore W52719346C54355233 @default.
- W52719346 hasConceptScore W52719346C71924100 @default.
- W52719346 hasConceptScore W52719346C81885089 @default.
- W52719346 hasConceptScore W52719346C86803240 @default.
- W52719346 hasConceptScore W52719346C87874733 @default.
- W52719346 hasConceptScore W52719346C94581717 @default.
- W52719346 hasLocation W527193461 @default.
- W52719346 hasLocation W527193462 @default.
- W52719346 hasOpenAccess W52719346 @default.
- W52719346 hasPrimaryLocation W527193461 @default.
- W52719346 hasRelatedWork W1546178979 @default.
- W52719346 hasRelatedWork W2021440792 @default.
- W52719346 hasRelatedWork W2040920323 @default.
- W52719346 hasRelatedWork W2091569641 @default.
- W52719346 hasRelatedWork W2165919621 @default.
- W52719346 hasRelatedWork W2312031035 @default.
- W52719346 hasRelatedWork W2356827444 @default.
- W52719346 hasRelatedWork W2369887333 @default.
- W52719346 hasRelatedWork W2973079820 @default.
- W52719346 hasRelatedWork W52719346 @default.
- W52719346 isParatext "false" @default.
- W52719346 isRetracted "false" @default.
- W52719346 magId "52719346" @default.
- W52719346 workType "book-chapter" @default.