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- W52764 abstract "This chapter explores the role of free radical scavengers and spin trapping agents in preventing cell death. Reactive oxygen species (ROS) can be generated in ischemic/reperfused tissues by a number of pathways. Electron transport associated with mitochondrial membranes is a major contributor to ROS formation in the normoxic brain. Enhancement of oxidative metabolism during the reperfusion phase following an ischemic episode may result in an overwhelming of the endogenous antioxidant capacity of the tissues. Purine metabolism provides another potential source of ROS. Because of the failure of oxidative phosphorylation, ATP levels decline precipitously, with the formation of adenosine and its metabolites inosine and hypoxanthine. Experimental evidence strongly implicates ROS in the chain of events leading to ischemia/reperfusion-related neuronal injuries. Free radical scavengers, spin-trapping agents, and inhibitors of the ROS synthesizing enzymes are able to interrupt the chain reaction of lipid peroxidation which can cause extensive destruction of plasma, nuclear, and mitochondrial membranes, leading to a failure of cellular metabolism, homeostasis, and ultimately to cell death. Agents such as the spin trap agent N - t -butyl-α-phenylnitrone and the antioxidant 21-aminosteroid, tirilazad mesylate, appear to offer promising new avenues of approach to the prevention and treatment of cerebral ischemic injuries." @default.
- W52764 created "2016-06-24" @default.
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- W52764 date "1997-01-01" @default.
- W52764 modified "2023-09-27" @default.
- W52764 title "Free Radical Scavengers and Spin Traps" @default.
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- W52764 doi "https://doi.org/10.1016/b978-012743170-3.50076-5" @default.
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