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• W52824108 abstract "Publisher Summary This chapter reviews methods for bioassay and purification as well as molecular and morphological characterization of the scrapie prion. The unusual molecular properties of the scrapie agent seem to distinguish it from both viruses and viroids and have led to the introduction of the term prion for the infectious particle. Procedures that hydrolyze or modify proteins produced a diminution of scrapie prion infectivity; in contrast, procedures that hydrolyze or modify nucleic acids do not alter the infectivity. At present, the only methods for measuring scrapie prion infectivity remain the incubation time interval assay and the end-point titration. Both methods are extremely slow because they require waiting for the onset of clinical neurological dysfunction, following a prolonged incubation period. An end-point titration for the scrapie prion is performed by serially diluting a sample at 10-fold increments. Each dilution is typically inoculated intracerebrally into four to six animals and the waiting process ensues. As the highest dilutions at which scrapie develops are the only observations of interest, 10–12 months must be allowed to pass before the titration may be scored if mice are used." @default.
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• W52824108 date "1984-01-01" @default.
• W52824108 modified "2023-10-13" @default.
• W52824108 title "Prions: Methods for Assay, Purification, and Characterization" @default.
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• W52824108 doi "https://doi.org/10.1016/b978-0-12-470208-0.50014-1" @default.
• W52824108 hasPublicationYear "1984" @default.
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