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- W5285369 abstract "Parkinson’s disease, the most common movement disorder, is characterized by nerve cell loss in the substantia nigra and other brain regions and the presence of filamentous α-synuclein inclusions in nerve cell bodies and processes (also known as Lewy bodies and Lewy neurites). Similar inclusions define the Lewy body dementias, as well as a number of other, less common neurodegenerative diseases. Some inherited forms of Parkinson’s disease and Lewy body dementias are caused by missense mutations in the α-synuclein gene or by the overproduction of wild-type α-synuclein, establishing that dysfunction of α-synuclein is sufficient to cause Parkinson’s disease and Lewy body dementias." @default.
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- W5285369 date "2009-01-01" @default.
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- W5285369 title "Parkinson’s Disease: Alpha-Synuclein and Neurodegeneration" @default.
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- W5285369 doi "https://doi.org/10.1016/b978-008045046-9.00512-x" @default.
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