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- W52901267 abstract "Abstract Astrocytes and microglia are phagocytic cell types in the central nervous system (CNS) that are often activated following virus infection in the brain and may play an important role in initiating the innate immune response to virus infection. However, there is lack of information on the responses by astrocytes and microglia following activation by virus-sensing Toll like-receptors such as TLR7, which recognizes viral ssRNA, and TLR9, which recognizes unmethylated CpG DNA. In the present study, we examined the cytokine and chemokine profiles, as well as the signaling molecules induced in astrocytes and microglia following stimulation of TLR7 and/or TLR9. Although both astrocytes and microglia produced proinflammatory cytokines and chemokines as a response to TLR7/9 stimulation, microglia also produced anti-inflammatory and neuroprotective cytokines while astrocytes did not. In general, TLR7 stimulation induced higher levels of proinflammatory cytokines and chemokines than TLR9 stimulation in both cell types. However, a high concentration of TLR7 agonist suppressed both TLR7 and TLR9-induced proinflammatory responses, suggesting a negative feedback mechanism in astrocytes and microglia in response to high levels of TLR7 ligands." @default.
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- W52901267 date "2009-04-01" @default.
- W52901267 modified "2023-09-26" @default.
- W52901267 title "Different innate immune profiles by astrocytes and microglia following TLR7 and/or TLR9 agonist stimulation (135.12)" @default.
- W52901267 doi "https://doi.org/10.4049/jimmunol.182.supp.135.12" @default.
- W52901267 hasPublicationYear "2009" @default.
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