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- W52924111 abstract "Publisher Summary This chapter presents a study examining heterogeneity of Sezary cells multiparameter approach in two cases. Two patients, a 56-year-old woman and a 71-year-old woman, were diagnosed as having Sezary Syndrome on the basis of clinical, histopathological, hematological, and ultrastructural criteria. Peripheral blood mononuclear cells were obtained by Ficoll/Paque density gradient centrifugation. More than 85% of isolated mononuclear cells had cerebriform nuclei as seen by electron microscopy. A series of monoclonal antibodies was utilized for membrane antigen recognition in an indirect immunofluorescence assay using F(ab′) 2 fragments of a goat anti-mouse immunoglobulin antiserum. Atypical cells from both cases exhibited a phenotype currently associated with mature T helper lymphocytes, being OKT3 and OKT4 positive, and OKT8 negative." @default.
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- W52924111 date "1984-01-01" @default.
- W52924111 modified "2023-09-24" @default.
- W52924111 title "Heterogeneity of Sézary cells. Multiparameter approach in two cases" @default.
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- W52924111 doi "https://doi.org/10.1016/b978-0-407-00338-5.50034-x" @default.
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