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- W53008087 abstract "Hypertension is a very common disorder. One-third of the US population has hypertension or is under antihypertensive medication. In addition, 45 million adults in the United States (20% of the total population) suffer from prehypertension. An important emerging concept is that hypertension is frequently associated with additional co-morbidities that contribute to increasing cardiovascular risk. Actually, hypertension represents a major risk factor for vascular, cardiac, renal and cerebral pathology, so that the existence of the so-called target organ damage (in vessels, heart, kidneys and brain) is a criterion for assessing the clinical severity of the disease. Hypothyroidism represents the most common thyroid function disorder; worldwide, the prevalence of hypothyroidism varies with iodine intake and clearly increases with age, reaching up to 20% in women aged more than 60 years. The foremost cause of congenital hypothyroidism remains endemic iodine deficiency and, in adults, chronic autoimmune (Hashimoto's) thyroiditis, which is more common in geographic areas of higher dietary iodine. The prevalence of hypertension in hypothyroid subjects is nearly triple that seen in the general population. Moreover, the significant correlations found between TH levels and diastolic BP suggests that TH deficiency per se may contribute to an increase in pressure values. Increased total and LDL cholesterol, triglycerides and oxidized low-density lipoproteins have been reported in patients with overt hypothyroidism. A TH defect is also associated with significant changes in HDL, with a hypercoagulable state and with elevated C-reactive protein and homocysteine levels, insulin resistance and arterial stiffness." @default.
- W53008087 created "2016-06-24" @default.
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- W53008087 date "2009-01-01" @default.
- W53008087 modified "2023-09-23" @default.
- W53008087 title "Hypertension and Hypothyroidism" @default.
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- W53008087 doi "https://doi.org/10.1016/b978-0-12-374135-6.00109-6" @default.
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