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- W53013579 abstract "Nineteen children with colitis (14 with ulcerative colitis and 5 with Crohn's colitis) were analyzed according to newly established criteria. There were 8 boys and 11 girls (mean age 12.3 ± 3.8 years), and duration of acute illness ranged from 2 to 56 days at the time of presentation. Six episodes responded to medical management within 12 days; one episode responded at 3 weeks, one at 4 weeks, and one had not responded when the patient was lost to follow-up. Extending the period of medical treatment beyond 12 days substantially increased morbidity and complications of therapy. No combination of criteria accurately predicted those patients who would respond to medical therapy alone. Ten episodes unresponsive to medical treatment required surgery for control of disease. Of the group who had responded to medical therapy, 5 of the 9 patients required proctocolectomy for intractable disease in the 2-year period after the severe attack, 3 others are doing poorly on a medical regimen (1.5-2.5 years later), and only 1 is in remission (5 years after the severe attack). The data demonstrate that 32% of children with severe colitis had a rapid response to medical management, but the remission achieved was short-lived. The majority of pediatric patients with severe colitis require surgery within 2 years of the onset of the attack." @default.
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- W53013579 date "1977-10-01" @default.
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- W53013579 title "Severe Colitis in Children and Adolescents: Diagnosis, Course, and Treatment" @default.
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- W53013579 doi "https://doi.org/10.1016/s0016-5085(19)31792-5" @default.
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