Matches in SemOpenAlex for { <https://semopenalex.org/work/W53077076> ?p ?o ?g. }
- W53077076 abstract "Drug design in aggressive cancers such as melanoma is challenged by a heterogeneous histopathology and the acquisition of a plethora of genetic and epigenetic alterations. Drug pumps, detoxification mechanisms, defects in programmed forms of cell death, and activation of survival mechanisms contribute to resistance to standard therapeutic agents. Here we describe the identification and functional validation of BO-110, a new double-stranded (ds)RNA-based nanocomplex that we found as a potent anti-cancer agent in vivo. First tested in melanoma cells, BO-110 was found to induce a tumor-cell selective killing by a combined activation of autophagy and apoptosis, in part via the innate immunity sensor Melanoma Differentiation-Associated gene-5 (MDA5), a cytosolic dsRNA helicase. A key effector of the innate responses by BO-110 is the pro-apoptotic protein NOXA, which this compound induces in a manner not recapitulated by classical chemo or immunotherapeutic agents. Importantly, BO-110 is highly effective against a broad spectrum of cancer types, while maintaining the viability of normal cells of different lineages. Therefore, dsRNA nanoplexes promote a combined activation of RNA helicases, autophagy, and apoptosis that can be exploited therapeutically in otherwise highly resistant human cancers." @default.
- W53077076 created "2016-06-24" @default.
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- W53077076 date "2014-01-01" @default.
- W53077076 modified "2023-10-18" @default.
- W53077076 title "BO-110, a dsRNA-Based Anticancer Agent" @default.
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- W53077076 doi "https://doi.org/10.1007/978-3-319-08084-0_16" @default.
- W53077076 hasPublicationYear "2014" @default.
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