Matches in SemOpenAlex for { <https://semopenalex.org/work/W53086750> ?p ?o ?g. }
- W53086750 endingPage "136" @default.
- W53086750 startingPage "119" @default.
- W53086750 abstract "The rationale behind the design of α-oligonucleotides concerns the concept of chimeric nucleic acids which could exhibit enzymatic stability and yet retain the ability to base pair with a complementary β-strand. Considering the basic chemical structure of a natural DNA (Figure 6.1), one can envisage three possible sites of chemical modification: the base, the phosphate and the sugar moiety. At first glance, base modifications cannot be considered, as we have to keep Watson-Crick (or Hoogsteen) base pairing, in order to retain hybridization with nucleic acid. Modifications of the phosphate backbone have been intensively explored since the pioneering work of Miller and Ts’o (Miller et al., 1986), who introduced a methyl group on the phosphorus atom to produce the methylphosphonate derivatives. The aim of this chapter is not to review the various phosphate backbone modified oligonucleotides, so we will not comment further on this approach. However, we would like to make two comments on phosphate backbone modified oligos. (1) As their synthesis is not stereocontroiled, this results in a mixture of 2 n diastereoisomers, where n is the number of P atoms. Among all of them, only one is expected to present the optimum hybridization properties. (2) Replacement of the negatively charged oxygen atom by a neutral group could interfere with eventual enzymatic interactions and also with the hydrophilic properties of the oligomers." @default.
- W53086750 created "2016-06-24" @default.
- W53086750 creator A5034750706 @default.
- W53086750 creator A5069624232 @default.
- W53086750 creator A5071109351 @default.
- W53086750 creator A5079289816 @default.
- W53086750 creator A5079727837 @default.
- W53086750 creator A5090061858 @default.
- W53086750 date "1989-01-01" @default.
- W53086750 modified "2023-10-16" @default.
- W53086750 title "α-Oligodeoxynucleotide Analogues" @default.
- W53086750 cites W1592020058 @default.
- W53086750 cites W1964042633 @default.
- W53086750 cites W1973003723 @default.
- W53086750 cites W1986323579 @default.
- W53086750 cites W1988262118 @default.
- W53086750 cites W1990754282 @default.
- W53086750 cites W1991335527 @default.
- W53086750 cites W1999146889 @default.
- W53086750 cites W2001233143 @default.
- W53086750 cites W2003598383 @default.
- W53086750 cites W2004406368 @default.
- W53086750 cites W2011283083 @default.
- W53086750 cites W2017731406 @default.
- W53086750 cites W2023226798 @default.
- W53086750 cites W2027910597 @default.
- W53086750 cites W2030401961 @default.
- W53086750 cites W2031577816 @default.
- W53086750 cites W2037783365 @default.
- W53086750 cites W2039534591 @default.
- W53086750 cites W2044443446 @default.
- W53086750 cites W2050944106 @default.
- W53086750 cites W2054946597 @default.
- W53086750 cites W2057667927 @default.
- W53086750 cites W2073252058 @default.
- W53086750 cites W2082545109 @default.
- W53086750 cites W2086010638 @default.
- W53086750 cites W2086299962 @default.
- W53086750 cites W2128061605 @default.
- W53086750 cites W2130528395 @default.
- W53086750 cites W2130917153 @default.
- W53086750 cites W2312886680 @default.
- W53086750 cites W4256412995 @default.
- W53086750 doi "https://doi.org/10.1007/978-1-349-10869-5_7" @default.
- W53086750 hasPublicationYear "1989" @default.
- W53086750 type Work @default.
- W53086750 sameAs 53086750 @default.
- W53086750 citedByCount "5" @default.
- W53086750 countsByYear W530867502018 @default.
- W53086750 crossrefType "book-chapter" @default.
- W53086750 hasAuthorship W53086750A5034750706 @default.
- W53086750 hasAuthorship W53086750A5069624232 @default.
- W53086750 hasAuthorship W53086750A5071109351 @default.
- W53086750 hasAuthorship W53086750A5079289816 @default.
- W53086750 hasAuthorship W53086750A5079727837 @default.
- W53086750 hasAuthorship W53086750A5090061858 @default.
- W53086750 hasConcept C104317684 @default.
- W53086750 hasConcept C129312508 @default.
- W53086750 hasConcept C138716334 @default.
- W53086750 hasConcept C178790620 @default.
- W53086750 hasConcept C185581394 @default.
- W53086750 hasConcept C185592680 @default.
- W53086750 hasConcept C21951064 @default.
- W53086750 hasConcept C24107716 @default.
- W53086750 hasConcept C2776568683 @default.
- W53086750 hasConcept C2777132085 @default.
- W53086750 hasConcept C2780535078 @default.
- W53086750 hasConcept C512185932 @default.
- W53086750 hasConcept C552990157 @default.
- W53086750 hasConcept C55493867 @default.
- W53086750 hasConcept C61234307 @default.
- W53086750 hasConcept C71240020 @default.
- W53086750 hasConceptScore W53086750C104317684 @default.
- W53086750 hasConceptScore W53086750C129312508 @default.
- W53086750 hasConceptScore W53086750C138716334 @default.
- W53086750 hasConceptScore W53086750C178790620 @default.
- W53086750 hasConceptScore W53086750C185581394 @default.
- W53086750 hasConceptScore W53086750C185592680 @default.
- W53086750 hasConceptScore W53086750C21951064 @default.
- W53086750 hasConceptScore W53086750C24107716 @default.
- W53086750 hasConceptScore W53086750C2776568683 @default.
- W53086750 hasConceptScore W53086750C2777132085 @default.
- W53086750 hasConceptScore W53086750C2780535078 @default.
- W53086750 hasConceptScore W53086750C512185932 @default.
- W53086750 hasConceptScore W53086750C552990157 @default.
- W53086750 hasConceptScore W53086750C55493867 @default.
- W53086750 hasConceptScore W53086750C61234307 @default.
- W53086750 hasConceptScore W53086750C71240020 @default.
- W53086750 hasLocation W530867501 @default.
- W53086750 hasOpenAccess W53086750 @default.
- W53086750 hasPrimaryLocation W530867501 @default.
- W53086750 hasRelatedWork W1965589588 @default.
- W53086750 hasRelatedWork W2033358700 @default.
- W53086750 hasRelatedWork W2128997110 @default.
- W53086750 hasRelatedWork W2301721694 @default.
- W53086750 hasRelatedWork W2429226674 @default.
- W53086750 hasRelatedWork W2490250157 @default.
- W53086750 hasRelatedWork W2888712311 @default.