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- W53101615 abstract "Palladium catalysis has emerged as an outstanding tool in synthetic organic chemistry for the mild and selective formation of carbon-carbon and carbon-heteroatom bonds. This thesis has been directed towards the extension of palladium(II)-catalyzed carbocyclization chemistry under oxidative conditions. An oxidative carbocyclization/functionalization methodology utilizing boron-containing transmetalation reagents was exploited to convert 1,5-allenynes into either arylated or borylated carbocycles. Two protocols were developed that use minimal amounts of Pd(OAc)2, stoichiometric para-benzoquinone as the oxidant and either bis(pinacolato)diboron or different arylboronic acids under mild conditions. A wide substrate scope is applicable to both methods. When the allenyne substrate bears a propargylic hydrogen, two isomeric functionalized carbocycles can be formed. By controlling the reaction conditions the reaction can be directed towards either of these two isomeric products. Kinetic isotope effect studies suggest that the mechanism leading to the different products proceeds through allylic or propargylic C-H bond cleavage, respectively. Moreover, it was observed that water has an interesting effect on the product selectivity when arylboronic acids are used in the oxidative carbocyclization of allenynes." @default.
- W53101615 created "2016-06-24" @default.
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- W53101615 date "2013-01-01" @default.
- W53101615 modified "2023-09-23" @default.
- W53101615 title "Investigation of Selectivity in Palladium-Catalyzed Oxidative Arylating Carbocyclization of Allenynes." @default.
- W53101615 hasPublicationYear "2013" @default.
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