Matches in SemOpenAlex for { <https://semopenalex.org/work/W53203901> ?p ?o ?g. }
- W53203901 endingPage "371" @default.
- W53203901 startingPage "349" @default.
- W53203901 abstract "Prepulse inhibition (PPI) of the startle response is an important measure of information processing deficits and inhibitory failure in schizophrenia patients. PPI is especially useful because it occurs in the same lawful manner in all mammals, from humans to rodents, making it an ideal candidate for cross-species translational research. PPI deficits occur across the schizophrenia spectrum from schizophrenia patients to their clinically unaffected relatives. Parallel animal model and human brain imaging studies have demonstrated that PPI is modulated by cortico-striato-pallido-thalamic (and pontine) circuitry. This circuitry is also implicated in schizophrenia neuropathology and neurophysiology. The finding of PPI deficits in schizophrenia patients has been replicated by many groups, and these deficits correlate with measures of thought disorder and appear to be normalized by second generation antipsychotic (SGA) medications. Consistent pharmacological effects on PPI have been demonstrated; among these, dopamine agonists induce PPI deficits and (in animal models) these are reversed by first and SGA medications. PPI is also significantly heritable in humans and animals and can be used as a powerful endophenotype in studies of families of schizophrenia patients. Genomic regions, including the NRGL-ERBB4 complex with its glutamatergic influences, are strongly implicated in PPI deficits in schizophrenia. PPI continues to hold promise as an exciting translational cross-species measure that can be used to understand the pathophysiology and treatment of the schizophrenias via pharmacological, anatomic, and genetic studies." @default.
- W53203901 created "2016-06-24" @default.
- W53203901 creator A5055966464 @default.
- W53203901 date "2010-01-01" @default.
- W53203901 modified "2023-10-06" @default.
- W53203901 title "Prepulse Inhibition of the Startle Reflex: A Window on the Brain in Schizophrenia" @default.
- W53203901 cites W147972831 @default.
- W53203901 cites W1546698346 @default.
- W53203901 cites W1600469961 @default.
- W53203901 cites W1757694062 @default.
- W53203901 cites W1963764462 @default.
- W53203901 cites W1968302946 @default.
- W53203901 cites W1970806342 @default.
- W53203901 cites W1973947372 @default.
- W53203901 cites W1974154075 @default.
- W53203901 cites W1974452539 @default.
- W53203901 cites W1975180862 @default.
- W53203901 cites W1979151871 @default.
- W53203901 cites W1980077228 @default.
- W53203901 cites W1980967004 @default.
- W53203901 cites W1982687579 @default.
- W53203901 cites W1984305433 @default.
- W53203901 cites W1984965974 @default.
- W53203901 cites W1986859027 @default.
- W53203901 cites W1989128230 @default.
- W53203901 cites W1989288468 @default.
- W53203901 cites W1989972781 @default.
- W53203901 cites W1990031045 @default.
- W53203901 cites W1990414759 @default.
- W53203901 cites W1990458727 @default.
- W53203901 cites W1991697613 @default.
- W53203901 cites W1994035129 @default.
- W53203901 cites W2003659920 @default.
- W53203901 cites W2004157112 @default.
- W53203901 cites W2005756201 @default.
- W53203901 cites W2005858623 @default.
- W53203901 cites W2008796546 @default.
- W53203901 cites W2014781793 @default.
- W53203901 cites W2015676687 @default.
- W53203901 cites W2016927854 @default.
- W53203901 cites W2018101275 @default.
- W53203901 cites W2020068013 @default.
- W53203901 cites W2020237866 @default.
- W53203901 cites W2021014490 @default.
- W53203901 cites W2022183380 @default.
- W53203901 cites W2022809683 @default.
- W53203901 cites W2024186806 @default.
- W53203901 cites W2025565335 @default.
- W53203901 cites W2026291661 @default.
- W53203901 cites W2026431974 @default.
- W53203901 cites W2030283288 @default.
- W53203901 cites W2031260481 @default.
- W53203901 cites W2033465981 @default.
- W53203901 cites W2037614370 @default.
- W53203901 cites W2042152382 @default.
- W53203901 cites W2042676846 @default.
- W53203901 cites W2043257432 @default.
- W53203901 cites W2044430408 @default.
- W53203901 cites W2044610927 @default.
- W53203901 cites W2045156432 @default.
- W53203901 cites W2045216666 @default.
- W53203901 cites W2045492160 @default.
- W53203901 cites W2048405858 @default.
- W53203901 cites W2048880280 @default.
- W53203901 cites W2050116887 @default.
- W53203901 cites W2053006968 @default.
- W53203901 cites W2053742943 @default.
- W53203901 cites W2054168131 @default.
- W53203901 cites W2058678287 @default.
- W53203901 cites W2059300794 @default.
- W53203901 cites W2060884332 @default.
- W53203901 cites W2061452688 @default.
- W53203901 cites W2061518358 @default.
- W53203901 cites W2062467533 @default.
- W53203901 cites W2062472783 @default.
- W53203901 cites W2062718409 @default.
- W53203901 cites W2068039132 @default.
- W53203901 cites W2068987805 @default.
- W53203901 cites W2070493747 @default.
- W53203901 cites W2072602941 @default.
- W53203901 cites W2073113115 @default.
- W53203901 cites W2074017648 @default.
- W53203901 cites W2074942168 @default.
- W53203901 cites W2078749292 @default.
- W53203901 cites W2079730191 @default.
- W53203901 cites W2082122713 @default.
- W53203901 cites W2083878293 @default.
- W53203901 cites W2084222335 @default.
- W53203901 cites W2085588350 @default.
- W53203901 cites W2088495467 @default.
- W53203901 cites W2089140125 @default.
- W53203901 cites W2089279096 @default.
- W53203901 cites W2090979638 @default.
- W53203901 cites W2093439527 @default.
- W53203901 cites W2094391126 @default.
- W53203901 cites W2094450187 @default.
- W53203901 cites W2094578990 @default.
- W53203901 cites W2095750371 @default.