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- W53204112 endingPage "114" @default.
- W53204112 startingPage "87" @default.
- W53204112 abstract "Death receptors are a subset of the tumor necrosis factor receptor (TNFR) family of proteins and share a characteristic cytoplasmic motif called the death domain. In addition to mediating cell death, these receptors regulate cell proliferation, inflammatory responses, and tumor progression. Receptor occupancy triggers the assembly of several cytoplasmic molecules into distinct complexes, each initiating separate signaling events leading to different biological responses. Post-translational modifications involving ubiquitin, a peptide of 76 amino acids, regulate events at nearly all stages of signaling. All ubiquitin chains function as docking platforms for molecules with specific recognition motifs that either propagate the signal or target the protein for proteasomal degradation. Moreover, enzymes with ubiquitin thioesterase activity (deubiquitinating enzymes, or DUBs) reverse modifications by removing the ubiquitin chains, allowing ubiquitin editing at the molecular level. Ubiquitin protein ligases (E3s), DUBs, and signaling molecules with ubiquitin recognition motifs control TNFR1 mediated cell death and activation of NF-kappaB and JNK. Here, we discuss the current understanding of how these proteins regulate TNFR1 signaling." @default.
- W53204112 created "2016-06-24" @default.
- W53204112 creator A5019102133 @default.
- W53204112 creator A5079412406 @default.
- W53204112 date "2009-01-01" @default.
- W53204112 modified "2023-09-27" @default.
- W53204112 title "Ubiquitination and TNFR1 Signaling" @default.
- W53204112 cites W135294775 @default.
- W53204112 cites W1482000562 @default.
- W53204112 cites W1535444616 @default.
- W53204112 cites W1560031613 @default.
- W53204112 cites W1570258903 @default.
- W53204112 cites W1585091528 @default.
- W53204112 cites W1780544763 @default.
- W53204112 cites W181940896 @default.
- W53204112 cites W1903448256 @default.
- W53204112 cites W1963819091 @default.
- W53204112 cites W1965453486 @default.
- W53204112 cites W1969796729 @default.
- W53204112 cites W1973462203 @default.
- W53204112 cites W1974652259 @default.
- W53204112 cites W1975826991 @default.
- W53204112 cites W1976141746 @default.
- W53204112 cites W1976382352 @default.
- W53204112 cites W1976765363 @default.
- W53204112 cites W1979595147 @default.
- W53204112 cites W1981890525 @default.
- W53204112 cites W1984710883 @default.
- W53204112 cites W1986706236 @default.
- W53204112 cites W1988376074 @default.
- W53204112 cites W1990752073 @default.
- W53204112 cites W1991131833 @default.
- W53204112 cites W1993936200 @default.
- W53204112 cites W1994874844 @default.
- W53204112 cites W1995747121 @default.
- W53204112 cites W1998423564 @default.
- W53204112 cites W1998815929 @default.
- W53204112 cites W1999982643 @default.
- W53204112 cites W2002154440 @default.
- W53204112 cites W2003225802 @default.
- W53204112 cites W2003534444 @default.
- W53204112 cites W2004821943 @default.
- W53204112 cites W2007093894 @default.
- W53204112 cites W2007456673 @default.
- W53204112 cites W2007731525 @default.
- W53204112 cites W2008584595 @default.
- W53204112 cites W2008646773 @default.
- W53204112 cites W2011640324 @default.
- W53204112 cites W2022247016 @default.
- W53204112 cites W2022598782 @default.
- W53204112 cites W2023073368 @default.
- W53204112 cites W2023746082 @default.
- W53204112 cites W2024587309 @default.
- W53204112 cites W2024836564 @default.
- W53204112 cites W2028882640 @default.
- W53204112 cites W2029454644 @default.
- W53204112 cites W2029731762 @default.
- W53204112 cites W2031106660 @default.
- W53204112 cites W2033495138 @default.
- W53204112 cites W2033562377 @default.
- W53204112 cites W2033703058 @default.
- W53204112 cites W2033734808 @default.
- W53204112 cites W2034580062 @default.
- W53204112 cites W2039355845 @default.
- W53204112 cites W2042087846 @default.
- W53204112 cites W2043141000 @default.
- W53204112 cites W2045022575 @default.
- W53204112 cites W2045991166 @default.
- W53204112 cites W2049781542 @default.
- W53204112 cites W2053550021 @default.
- W53204112 cites W2054313684 @default.
- W53204112 cites W2055514573 @default.
- W53204112 cites W2055573606 @default.
- W53204112 cites W2057123987 @default.
- W53204112 cites W2060060231 @default.
- W53204112 cites W2061296868 @default.
- W53204112 cites W2064122617 @default.
- W53204112 cites W2064299413 @default.
- W53204112 cites W2064396641 @default.
- W53204112 cites W2065036369 @default.
- W53204112 cites W2066327335 @default.
- W53204112 cites W2067913123 @default.
- W53204112 cites W2068010171 @default.
- W53204112 cites W2069681479 @default.
- W53204112 cites W2069800916 @default.
- W53204112 cites W2073167340 @default.
- W53204112 cites W2074097004 @default.
- W53204112 cites W2074982435 @default.
- W53204112 cites W2077121402 @default.
- W53204112 cites W2078297328 @default.
- W53204112 cites W2079833232 @default.
- W53204112 cites W2081933521 @default.
- W53204112 cites W2085926680 @default.
- W53204112 cites W2091161875 @default.
- W53204112 cites W2093475144 @default.
- W53204112 cites W2094863064 @default.
- W53204112 cites W2097672870 @default.
- W53204112 cites W2099760505 @default.