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• W53232322 endingPage "404" @default.
• W53232322 startingPage "391" @default.
• W53232322 abstract "The human endometrium (lining of the uterus) is a dynamic remodeling tissue undergoing more than 400 cycles of regeneration, differentiation, and shedding during a woman’s reproductive years. Endometrial regeneration also follows childbirth, almost complete resection and in postmenopausal women taking estrogen replacement therapy. In nonmenstruating species (e.g. rodents) there are cycles of endometrial growth and apoptosis, rather than physical shedding. The endometrium comprises epithelial-lined glands extending from the surface epithelium to the myometrium supported by extensive stroma. Remodeling of the endometrium is regulated by the co-ordinated and sequential actions of estrogen and progesterone in preparation for blastocyst implantation on a monthly basis in women and every 4–5 days in mice. Adult stem/progenitor cells are likely responsible for endometrial regeneration. Since there are no specific stem cell markers, initial studies using functional approaches identified candidate epithelial and stromal endometrial stem/progenitor cells as colony-forming cells/units (CFU) and side population (SP) cells. Recently, a subpopulation of human endometrial stromal cells with mesenchymal stem cell–like properties of CFU activity and multilineage differentiation have been isolated by their co-expression of CD146 and PDGF-receptor $beta$ . Candidate epithelial and stromal stem/progenitor cells have also been identified in mouse endometrium as rare label-retaining cells (LRC) in the luminal epithelium and as perivascular cells at the endometrial myometrial junction, respectively. While epithelial and most stromal LRC do not express estrogen receptor α (ERα), they rapidly proliferate on estrogen stimulation, most likely mediated by neighboring ERα-expressing niche cells. It is likely that these newly identified endometrial stem/progenitor cells may play key roles in the development of gynecological diseases associated with abnormal endometrial proliferation such as endometriosis and endometrial cancer. The endometrium may also provide a readily available source of mesenchymal stem-like cells for tissue engineering purposes with possible applications not only to urogynecology but also to heart disease, and soft tissue and bone repair." @default.
• W53232322 created "2016-06-24" @default.
• W53232322 creator A5012509613 @default.
• W53232322 creator A5044939352 @default.
• W53232322 date "2009-01-01" @default.
• W53232322 modified "2023-09-24" @default.
• W53232322 title "The Endometrium: A Novel Source of Adult Stem/Progenitor Cells" @default.
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• W53232322 doi "https://doi.org/10.1007/978-1-60327-227-8_32" @default.
• W53232322 hasPublicationYear "2009" @default.

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