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- W53242751 abstract "1172 Objectives In combined positron emission tomography (PET) and computed tomography (CT) imaging, oral and intravenous (IV) contrast can be administered for improving diagnostic value. Since a HU-dependent density-map is used, CT contrast agents may induce PET artifacts due to overestimation of attenuation in regions with contrast-enhancement. Our goal was to determine the effect of IV-contrast on the standard uptake value (SUV) in 18F-FDG PET-CT in a routine clinical setting and by using a test-retest study design. Methods Twenty patients referred for oncological indications received two sequential PET-CT scans (Philips, Gemini TF16). PET1 (90 min p.i.) is acquired before and PET2 (135 min p.i.) after administration of oral and IV-contrast. Radiotherapy settings were used to facilitate re-alignment. SUVmean and HU were calculated in two non-tumor regions (liver (N=17) and spleen (N=18)) as well as in 12 tumor lesion volumes (4 liver and 8 lung lesions). To investigate alterations in 18F-FDG-uptake, the average count difference between non-attenuation corrected PET datasets were calculated in both standard regions and lesion volumes. The net difference between PET1 and PET2 is expressed in the net effect. Conclusions Conclusion: both in standard tissues and in lesions, both SUV and net effect increases after administration of IV-contrast. This phenomenon can not be explained by the time interval or change of kinetics between PET1 and PET2. Clinical relevance may be considerable" @default.
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- W53242751 date "2010-05-01" @default.
- W53242751 modified "2023-09-24" @default.
- W53242751 title "Quantification of the effects of intravenous contrast on standard uptake value in 18F-FDG PET-CT using a test-retest approach" @default.
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