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- W53247830 abstract "Twenty-one patients with brain tumors were studied with /sup 18/F-deoxyglucose scanning. ''Dynamic'' scans were done at 2 1/2 minute intervals during the first 30 minutes of uptake, and two conventional scans were done at about one and two hours, respectively, after injection. Values of the rate constants k/sub 1/-k/sub 3/ and glucose metabolic rate R were obtained by fitting the curve of tissue uptake over the first 30 minutes to the 3-compartment model, and values of k/sub 4/ were obtained by comparing the late scan with the last 3 dynamic scans and the 1 hour scan. There was no difference in rate constants, k/sub 1/-k/sub 3/ between normal cortical tissue and high or low grade gliomas. However the rate constants k/sub 1/ and k/sub 2/ obtained from the 30 minutes of dynamic scanning were 2-4 times higher than those reported by others for uptake curves measured over several hours. There was good correlation between metabolic rates determined from the first 30 minutes and from the conventional scan, and this correlation improved slightly when the conventional determination was made using fitted rate constants, but the dynamically obtained values were 10% higher than the conventional ones. These discrepancies may be related tomore » a non-equilibrium distribution of free tracer within the second compartment (tissue) at early times. The k/sub 4/ values did not differ overall among high-grade tumors, low-grade tumors, and normal cortex, although for six high grade tumors k/sub 4/ was 30% lower than the cortical k/sub 4/ for those six patients. This may indicate a slight reduction in phosphatase in high grade gliomas.« less" @default.
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- W53247830 date "1984-01-01" @default.
- W53247830 modified "2023-10-15" @default.
- W53247830 title "Dynamic rate constants for F-18-deoxyglucose uptake in normal and tumoral brain tissue" @default.
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