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• W53344902 abstract "RNA interference (RNAi) high-content screening (HCS) enables massive parallel gene silencing and is increasingly being used to reveal novel connections between genes and disease-relevant phenotypes. The application of genome-scale RNAi relies on the development of high quality HCS assays. Strictly standardized mean difference (SSMD), introduced by Zhang et al. [1], provides a possibility for hit selection in HCS experiments. This method has relied on normal approximation, which works in the primary screens considering positive and negative controls. This paper describes a new extension of the SSMD, which integrates bioinformatics RNAi on-target analysis results for both the SSMD-based testing process and the use of SSMDas a ranking metric for hit selection by using additional controls generated from RNAi libraries." @default.
• W53344902 created "2016-06-24" @default.
• W53344902 creator A5018072417 @default.
• W53344902 date "2012-01-01" @default.
• W53344902 modified "2023-09-23" @default.
• W53344902 title "The Use of Design Specificity in Standardized Mean Difference for Analysis of High throughput RNA Interference Screens" @default.
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• W53344902 doi "https://doi.org/10.1007/978-3-642-32395-9_11" @default.
• W53344902 hasPublicationYear "2012" @default.
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