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- W53376106 abstract "Treatment of CBA/Ca mice with cortisone acetate for a short period after infection with Trichuris muris induces a state of immunotolerance which allows the development and survival of a chronic infection. Mice harbouring such infections were found to be less capable of responding to a primary infection with Trichinella spiralis or of producing humoral responses to lipopolysaccharide and sheep red blood cells. Mesenteric lymph node T cells, however, were as responsive to the polyclonal activator phytohaemagglutinin as those from normal mice. Homing to the intestinal tract of activated mesenteric lymph node cells from helminth-infected donors was not impaired in the animals harbouring chronic infections. The results are discussed in terms of antigenic competition and with respect to their relevance to chronic human trichuriasis." @default.
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- W53376106 date "1983-03-01" @default.
- W53376106 modified "2023-10-18" @default.
- W53376106 title "Cortisone-induced immunotolerance to nematode infection in CBA/Ca mice. II. A model for human chronic trichuriasis." @default.
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