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- W5340422 abstract "This chapter focuses on the cardiac effects of ApnA and discusses the possible signaling role of these nucleotides in the heart. Diadenosine polyphosphates (ApnA) contain two adenosine moieties linked through ribose 5' carbons to a phosphate group chain, with the number of phosphate groups ( n ) from 2 to 6. In prokaryotic cells, changes in the concentration of cytosolic ApnA have been reported during stress and associated with inhibition of heat shock and oxidative stress proteins. ApnA are structurally related to ATP, and there are strong parallels between their cardiac actions. The greater stability of ApnA compared with mononucleotides and adenosine has significant implications with respect to their extracellular and intracellular actions. As this class of nucleotides is present in the heart; senses the metabolic state of the myocardium; and induces significant cardiac effects, including the regulation of contraction and excitation, and the regulation of cardioprotective mechanisms, therefore, one can conclude that ApnA harbor properties of signaling molecules in the heart." @default.
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- W5340422 date "2001-01-01" @default.
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- W5340422 title "Diadenosine Polyphosphate Signaling in the Heart" @default.
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- W5340422 doi "https://doi.org/10.1016/b978-012656975-9/50041-9" @default.
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