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- W53467020 abstract "Age-related macular degeneration (AMD) causes loss of central vision mediated by the macula, a portion of the retina specialized for fine acuity vision. AMD is the most common cause of blindness in elderly individuals. Drusen, extracellular deposits between Bruch's membrane and the retinal pigmented epithelium (RPE), are a hallmark of the disease. Compromise of RPE cells overlying drusen leads to dysfunction and death of the photoreceptor cells in the neural retina. Age, heredity, and smoking are the most significant risk factors for AMD. Polymorphisms in complement-related and other genes also contribute to the risk of AMD." @default.
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- W53467020 date "2010-01-01" @default.
- W53467020 modified "2023-09-26" @default.
- W53467020 title "Secondary Photoreceptor Degenerations: Age-Related Macular Degeneration" @default.
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