FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W53514369> ?p ?o ?g. }

• W53514369 endingPage "702" @default.
• W53514369 startingPage "694" @default.
• W53514369 abstract "Neonatal short bowel syndrome following massive gut resection is associated with malabsorption of nutrients. The intestinotrophic factor glucagon-like peptide 2 (GLP-2) improves gut function in adult patients with short bowel syndrome, but its effect in pediatric patients remains unknown. Our objective was to test the efficacy of the long-acting synthetic human GLP-2 analogue, teduglutide (ALX-0600), in a neonatal piglet jejunostomy model. Two-day-old pigs were subjected to resection of 50% of the small intestine (distal part), and the remnant intestine was exteriorized on the abdominal wall as a jejunostomy. All pigs were given total parenteral nutrition for 7 days and a single daily injection of the following doses of teduglutide: 0.01 (n = 6), 0.02 (n = 6), 0.1 (n = 5), or 0.2 mg · kg · day (n = 6), and compared with placebo (n = 9). Body weight increment was similar for all 4 teduglutide groups but higher than placebo (P < 0.05). There was a dose-dependent increase in weight per length of the remnant intestine (P < 0.01) and fractional protein synthesis rate in the intestine was increased in the 0.2 mg · kg · day group versus placebo (P < 0.001); however, functional and structural endpoints including activity of digestive enzymes, absorption of enteral nutrients, and immunohistochemistry (Ki67, villin, FABP2, ChgA, and GLP-2R) were not affected by the treatment. Teduglutide induces trophicity on the remnant intestine but has limited acute effects on functional endpoints. Significant effects of teduglutide on gut function may require a longer adaptation period and/or a more frequent administration of the peptide. In perspective, GLP-2 or its analogues may be relevant to improve intestinal adaptation in pediatric patients with short bowel syndrome." @default.
• W53514369 created "2016-06-24" @default.
• W53514369 creator A5018533843 @default.
• W53514369 creator A5038771299 @default.
• W53514369 creator A5043377405 @default.
• W53514369 creator A5049761975 @default.
• W53514369 creator A5059899906 @default.
• W53514369 creator A5067298078 @default.
• W53514369 creator A5074424756 @default.
• W53514369 creator A5086975889 @default.
• W53514369 creator A5088881255 @default.
• W53514369 date "2014-06-01" @default.
• W53514369 modified "2023-10-15" @default.
• W53514369 title "Acute Effects of the Glucagon-Like Peptide 2 Analogue, Teduglutide, on Intestinal Adaptation in Short Bowel Syndrome" @default.
• W53514369 cites W1964762675 @default.
• W53514369 cites W1970107152 @default.
• W53514369 cites W1982696037 @default.
• W53514369 cites W1983266690 @default.
• W53514369 cites W1989268172 @default.
• W53514369 cites W2002149953 @default.
• W53514369 cites W2011857225 @default.
• W53514369 cites W2016022622 @default.
• W53514369 cites W2031174985 @default.
• W53514369 cites W2035723938 @default.
• W53514369 cites W2039721097 @default.
• W53514369 cites W2046399107 @default.
• W53514369 cites W2053406839 @default.
• W53514369 cites W2063996354 @default.
• W53514369 cites W2085424664 @default.
• W53514369 cites W2100093779 @default.
• W53514369 cites W2106203516 @default.
• W53514369 cites W2107980888 @default.
• W53514369 cites W2138831474 @default.
• W53514369 cites W2145242908 @default.
• W53514369 cites W2151291353 @default.
• W53514369 cites W2160218747 @default.
• W53514369 cites W2161597130 @default.
• W53514369 cites W2175144036 @default.
• W53514369 cites W2320948890 @default.
• W53514369 cites W2322226086 @default.
• W53514369 doi "https://doi.org/10.1097/mpg.0000000000000295" @default.
• W53514369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24399211" @default.
• W53514369 hasPublicationYear "2014" @default.
• W53514369 type Work @default.
• W53514369 sameAs 53514369 @default.
• W53514369 citedByCount "38" @default.
• W53514369 countsByYear W535143692014 @default.
• W53514369 countsByYear W535143692015 @default.
• W53514369 countsByYear W535143692016 @default.
• W53514369 countsByYear W535143692017 @default.
• W53514369 countsByYear W535143692018 @default.
• W53514369 countsByYear W535143692019 @default.
• W53514369 countsByYear W535143692020 @default.
• W53514369 countsByYear W535143692021 @default.
• W53514369 countsByYear W535143692022 @default.
• W53514369 countsByYear W535143692023 @default.
• W53514369 crossrefType "journal-article" @default.
• W53514369 hasAuthorship W53514369A5018533843 @default.
• W53514369 hasAuthorship W53514369A5038771299 @default.
• W53514369 hasAuthorship W53514369A5043377405 @default.
• W53514369 hasAuthorship W53514369A5049761975 @default.
• W53514369 hasAuthorship W53514369A5059899906 @default.
• W53514369 hasAuthorship W53514369A5067298078 @default.
• W53514369 hasAuthorship W53514369A5074424756 @default.
• W53514369 hasAuthorship W53514369A5086975889 @default.
• W53514369 hasAuthorship W53514369A5088881255 @default.
• W53514369 hasBestOaLocation W535143691 @default.
• W53514369 hasConcept C126322002 @default.
• W53514369 hasConcept C134018914 @default.
• W53514369 hasConcept C142724271 @default.
• W53514369 hasConcept C204787440 @default.
• W53514369 hasConcept C27081682 @default.
• W53514369 hasConcept C2777226302 @default.
• W53514369 hasConcept C2777355116 @default.
• W53514369 hasConcept C2777882243 @default.
• W53514369 hasConcept C2779281246 @default.
• W53514369 hasConcept C2779820108 @default.
• W53514369 hasConcept C2780439177 @default.
• W53514369 hasConcept C2781219945 @default.
• W53514369 hasConcept C44315111 @default.
• W53514369 hasConcept C55493867 @default.
• W53514369 hasConcept C71924100 @default.
• W53514369 hasConcept C78722104 @default.
• W53514369 hasConcept C86803240 @default.
• W53514369 hasConcept C90924648 @default.
• W53514369 hasConceptScore W53514369C126322002 @default.
• W53514369 hasConceptScore W53514369C134018914 @default.
• W53514369 hasConceptScore W53514369C142724271 @default.
• W53514369 hasConceptScore W53514369C204787440 @default.
• W53514369 hasConceptScore W53514369C27081682 @default.
• W53514369 hasConceptScore W53514369C2777226302 @default.
• W53514369 hasConceptScore W53514369C2777355116 @default.
• W53514369 hasConceptScore W53514369C2777882243 @default.
• W53514369 hasConceptScore W53514369C2779281246 @default.
• W53514369 hasConceptScore W53514369C2779820108 @default.
• W53514369 hasConceptScore W53514369C2780439177 @default.
• W53514369 hasConceptScore W53514369C2781219945 @default.
• W53514369 hasConceptScore W53514369C44315111 @default.

• next