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• W5352568 abstract "ABSTRACT In order to understand the molecular basis of insulin action and the fate of the hormone in the organism, it is essential to obtain a complete picture of the relationships between primary structure, tertiary structure and biological properties. These studies require homogeneous analogues and derivatives. Strategies and tactics used in this Institute for the synthesis, semisynthesis and chemical modification of the native hormone are outlined. The procedures include total synthesis of A-chains, substitutions of amino and other functional groups, chain elongation, shortening of chains, replacement of amino acids and peptide fragments, and crosslinking. The effects of such modifications on biological activity in vitro and in vivo, on receptor binding, degradation, as well as on the structure of insulin in solution and in the crystal are described, and the results discussed on the basis of the threedimensional model of insulin. The paper summarizes results of cooperative structure-function studies carried out during the last 12 years." @default.
• W5352568 created "2016-06-24" @default.
• W5352568 creator A5046297999 @default.
• W5352568 date "1981-01-01" @default.
• W5352568 modified "2023-09-24" @default.
• W5352568 title "Relations Between the Structure and Biological Activity of Insulin" @default.
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• W5352568 doi "https://doi.org/10.1016/b978-0-08-025297-1.50043-x" @default.
• W5352568 hasPublicationYear "1981" @default.
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