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- W53690914 startingPage "CIN.S609" @default.
- W53690914 abstract "We identified gene expression signatures predicting responsiveness to a Kinesin-5 (KIF11) inhibitor (Kinesin-5i) in cultured colon tumor cell lines. Genes predicting resistance to Kinesin-5i were enriched for those from chromosome 20q, a region of frequent amplification in a number of tumor types. siRNAs targeting genes in this chromosomal region identified AURKA, TPX2 and MYBL2 as genes whose disruption enhances response to Kinesin-5i. Taken together, our results show functional interaction between these genes, and suggest that their overexpression is involved in resistance to Kinesin-5i. Furthermore, our results suggest that patients whose tumors overexpress AURKA due to amplification of 20q will more likely resist treatment with Kinesin-5 inhibitor, and that inactivation of AURKA may sensitize these patients to treatment." @default.
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- W53690914 date "2008-01-01" @default.
- W53690914 modified "2023-09-27" @default.
- W53690914 title "Chromosome 20q Amplification Regulates<i>in Vitro</i>Response to Kinesin-5 Inhibitor" @default.
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- W53690914 doi "https://doi.org/10.4137/cin.s609" @default.
- W53690914 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2621078" @default.
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