Matches in SemOpenAlex for { <https://semopenalex.org/work/W53779210> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W53779210 endingPage "2590" @default.
- W53779210 startingPage "2583" @default.
- W53779210 abstract "AIM: To investigate the efficacy of a Chinese medicine, Yi-gan-kang granule (granules for benefiting the liver), in prophylaxis and treatment of liver fibrosis in rats and its possible mechanism.METHODS: One hundred and forty Sprague-Dawley rats were randomly divided into seven groups (20 each): group 1, blank control group without any interference during the study; group 2, CCl4-induced liver fibrosis group; group 3, pig serum-induced liver fibrosis group; group 4, prophylaxis group of CCl4-induced liver fibrosis by Yi-gan-kang, group 5,prophylaxis group of pig serum-induced liver fibrosis by Yi-gan-kang, group 6, treatment group of CCl4-induced liver fibrosis by Yi-gan-kang, group 7, treatment group of CCl4-induced liver fibrosis by Yi-gan-kang. At wk 6, 10, 14 and 20(baseline for CCl4 or big serum induction), five rats in each group were anesthetized and their livers were removed for pathological studies including immunohistochemicalstudies for α-SMA, type Ⅰ collagen and in situ hybridization of tissue inhibitor of metalloproteinase-1 (TIMP-1) mRNA of hepatic stellate cells (HSCs). Anti-lipid peroxidation in isolated mitochondria and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) colorimetric assay for proliferation and terminal deoxynucleotidyl transferasemedicated dUTP-biotin nick end-labeling (TUNEL), flow cytometry and electron microscopy for apoptosis in isolated HSCs were also studied.RESULTS: The mean number of pseudolobuli at wk 10,14 and 20 in the prophylaxis group was significantly less than that in the control group (P＜0.05 or 0.01). The effectof prophylaxis at wk 14 in CCl4 rats and at wk 10 in pig serum-induced rats was much better than that of treatment group (P＜0.01). The thickness (in μm) of fibers both in pig serum-induced prophylaxis and in treatment groups at wk 14 and. 20 was significantly less than that in control group (P＜0.05). The number of fibers both in prophylaxis and in treatment groups from wk 10 or 14 to 20 was significantly less than that in control" @default.
- W53779210 created "2016-06-24" @default.
- W53779210 creator A5002472052 @default.
- W53779210 creator A5027495236 @default.
- W53779210 creator A5065152362 @default.
- W53779210 creator A5066007775 @default.
- W53779210 creator A5070800628 @default.
- W53779210 date "2005-01-01" @default.
- W53779210 modified "2023-09-23" @default.
- W53779210 title "Efficacy of Chinese medicine Yi-gan-kang granule in prophylaxis and treatment of liver fibrosis in rats" @default.
- W53779210 hasPublicationYear "2005" @default.
- W53779210 type Work @default.
- W53779210 sameAs 53779210 @default.
- W53779210 citedByCount "0" @default.
- W53779210 crossrefType "journal-article" @default.
- W53779210 hasAuthorship W53779210A5002472052 @default.
- W53779210 hasAuthorship W53779210A5027495236 @default.
- W53779210 hasAuthorship W53779210A5065152362 @default.
- W53779210 hasAuthorship W53779210A5066007775 @default.
- W53779210 hasAuthorship W53779210A5070800628 @default.
- W53779210 hasConcept C102124568 @default.
- W53779210 hasConcept C126322002 @default.
- W53779210 hasConcept C134018914 @default.
- W53779210 hasConcept C142724271 @default.
- W53779210 hasConcept C176891718 @default.
- W53779210 hasConcept C178790620 @default.
- W53779210 hasConcept C185592680 @default.
- W53779210 hasConcept C188947578 @default.
- W53779210 hasConcept C190283241 @default.
- W53779210 hasConcept C196795494 @default.
- W53779210 hasConcept C204232928 @default.
- W53779210 hasConcept C204787440 @default.
- W53779210 hasConcept C2777359374 @default.
- W53779210 hasConcept C2780559512 @default.
- W53779210 hasConcept C2993667909 @default.
- W53779210 hasConcept C55493867 @default.
- W53779210 hasConcept C71924100 @default.
- W53779210 hasConcept C86803240 @default.
- W53779210 hasConcept C90924648 @default.
- W53779210 hasConceptScore W53779210C102124568 @default.
- W53779210 hasConceptScore W53779210C126322002 @default.
- W53779210 hasConceptScore W53779210C134018914 @default.
- W53779210 hasConceptScore W53779210C142724271 @default.
- W53779210 hasConceptScore W53779210C176891718 @default.
- W53779210 hasConceptScore W53779210C178790620 @default.
- W53779210 hasConceptScore W53779210C185592680 @default.
- W53779210 hasConceptScore W53779210C188947578 @default.
- W53779210 hasConceptScore W53779210C190283241 @default.
- W53779210 hasConceptScore W53779210C196795494 @default.
- W53779210 hasConceptScore W53779210C204232928 @default.
- W53779210 hasConceptScore W53779210C204787440 @default.
- W53779210 hasConceptScore W53779210C2777359374 @default.
- W53779210 hasConceptScore W53779210C2780559512 @default.
- W53779210 hasConceptScore W53779210C2993667909 @default.
- W53779210 hasConceptScore W53779210C55493867 @default.
- W53779210 hasConceptScore W53779210C71924100 @default.
- W53779210 hasConceptScore W53779210C86803240 @default.
- W53779210 hasConceptScore W53779210C90924648 @default.
- W53779210 hasIssue "17" @default.
- W53779210 hasLocation W537792101 @default.
- W53779210 hasOpenAccess W53779210 @default.
- W53779210 hasPrimaryLocation W537792101 @default.
- W53779210 hasRelatedWork W1444146890 @default.
- W53779210 hasRelatedWork W181901118 @default.
- W53779210 hasRelatedWork W210399354 @default.
- W53779210 hasRelatedWork W2330700534 @default.
- W53779210 hasRelatedWork W2332586109 @default.
- W53779210 hasRelatedWork W2347360536 @default.
- W53779210 hasRelatedWork W2348443331 @default.
- W53779210 hasRelatedWork W2353013375 @default.
- W53779210 hasRelatedWork W2356558875 @default.
- W53779210 hasRelatedWork W2358938374 @default.
- W53779210 hasRelatedWork W2359883806 @default.
- W53779210 hasRelatedWork W2371146939 @default.
- W53779210 hasRelatedWork W2373825158 @default.
- W53779210 hasRelatedWork W2380647682 @default.
- W53779210 hasRelatedWork W2384125588 @default.
- W53779210 hasRelatedWork W2384327212 @default.
- W53779210 hasRelatedWork W2386010556 @default.
- W53779210 hasRelatedWork W3141869046 @default.
- W53779210 hasRelatedWork W332973065 @default.
- W53779210 hasRelatedWork W333129037 @default.
- W53779210 hasVolume "11" @default.
- W53779210 isParatext "false" @default.
- W53779210 isRetracted "false" @default.
- W53779210 magId "53779210" @default.
- W53779210 workType "article" @default.