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- W53782943 abstract "Cancer risk carries wide interindividual variation; only a fraction of the population exposed to a known carcinogen develops cancer. Genetic susceptibility is both inherited and acquired. Genes that affect cancer susceptibility can be found in those controlling behavior, carcinogen metabolism, and cellular response to carcinogen exposure. Genetic traits affect DNA repair, cell cycle control, and immune response. Polymorphic genetic variants are under intense study. It stands to reason that if genetic traits that affect cancer risk can be measured, these traits would also govern responses to cancer prevention strategies such as chemoprevention. Cancer prevention strategies may become more focused if it is possible to identify susceptible subgroups of the population. Thus, incorporating such measures should lead to more rational chemoprevention studies, allowing for smaller sample size and shorter duration. This chapter describes concepts underlying genetic susceptibility and current technology used to assess it, provides specific examples of low-penetrance genes involved in cancer susceptibility, and comments on the implications for cancer prevention." @default.
- W53782943 created "2016-06-24" @default.
- W53782943 creator A5020391084 @default.
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- W53782943 date "2005-01-01" @default.
- W53782943 modified "2023-09-23" @default.
- W53782943 title "Genetic Polymorphisms and Risk Assessment for Cancer Chemoprevention" @default.
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- W53782943 doi "https://doi.org/10.1007/978-1-59259-768-0_12" @default.
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