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- W5378932 endingPage "259" @default.
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- W5378932 abstract "Unlike other hypothalamic neuropeptide-producing cells, GnRH neurons do not arise from the developing basal forebrain. They originate in the olfactory placode in mammals and migrate across the nasal cavity and cribiform plate into the forebrain (1, 2). In mice, for example, the GnRH neurons are derived from the neural ectoderm, are born on d 10.5 postcoitus (pc), and begin to express GnRH mRNA and protein between d 10.75 and 11.5 pc. GnRH neurons then migrate across the olfactory cavity to the forebrain between d 12.5 pc and d 16.5 pc (2, 3). GnRH neurons migrating across the nasal cavity appear to be guided, in part, by the polysialic acid-rich form of the neural cell adhesion molecule (PSA-NCAM) (4) in association with the vomeronasal nerves (VNN). Recent evidence in studies of chick forebrain development has further implicated PSA-NCAM as an important component in GnRH neuronal migration (5). Other investigators have posited that factors such as gamma aminobutyric acid (GABA) (6, 7), adhesion-related kinase (8), or peripherin (9) might play a role in the guidance of the GnRH neurons. The initial migration to the forebrain follows the vomeronasal and terminal nerves. However, after entering the rostral forebrain, GnRH neurons become disassociated from the caudal branch of the VNN. Therefore, it is unclear what guides them during the remaining portion of their migration to the basal hypothalamus. At this time, it is felt that GnRH neurons are no longer guided by a defined anatomical structure (10). Instead, neuronal migration may trail behind as axonal migration to the median eminence and organum vasculosum of the lamina terminalis (OVLT) is occurring." @default.
- W5378932 created "2016-06-24" @default.
- W5378932 creator A5002688048 @default.
- W5378932 creator A5012068391 @default.
- W5378932 creator A5027063862 @default.
- W5378932 creator A5056214662 @default.
- W5378932 creator A5070839835 @default.
- W5378932 date "2002-01-01" @default.
- W5378932 modified "2023-09-26" @default.
- W5378932 title "Transcriptional Development of the Hypothalamic-Pituitary-Gonadal Axis" @default.
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