FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W53848852> ?p ?o ?g. }

• W53848852 endingPage "4141" @default.
• W53848852 startingPage "4130" @default.
• W53848852 abstract "Research Article15 August 1996free access Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types. W. Zhu W. Zhu Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada. Search for more papers by this author A. Cowie A. Cowie Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada. Search for more papers by this author G. W. Wasfy G. W. Wasfy Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada. Search for more papers by this author L. Z. Penn L. Z. Penn Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada. Search for more papers by this author B. Leber B. Leber Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada. Search for more papers by this author D. W. Andrews D. W. Andrews Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada. Search for more papers by this author W. Zhu W. Zhu Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada. Search for more papers by this author A. Cowie A. Cowie Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada. Search for more papers by this author G. W. Wasfy G. W. Wasfy Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada. Search for more papers by this author L. Z. Penn L. Z. Penn Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada. Search for more papers by this author B. Leber B. Leber Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada. Search for more papers by this author D. W. Andrews D. W. Andrews Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada. Search for more papers by this author Author Information W. Zhu1, A. Cowie1, G. W. Wasfy1, L. Z. Penn1, B. Leber1 and D. W. Andrews1 1Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada. The EMBO Journal (1996)15:4130-4141https://doi.org/10.1002/j.1460-2075.1996.tb00788.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Human Bcl-2 is located in multiple intracellular membranes when expressed in MDCK and Rat-1/myc cells. We restricted expression to the endoplasmic reticulum or mitochondria by exchanging the Bcl-2 carboxy-terminal insertion sequence for an equivalent sequence from cytochrome b5 or ActA, respectively. MDCK cells are protected from serum deprivation-induced apoptosis by both wild-type Bcl-2 and the mutant targeted to mitochondria but not by the mutant targeted to endoplasmic reticulum. In contrast, when expressed in Rat-1/myc cells, the Bcl-2 mutant located at the endoplasmic reticulum is more effective than that targeted to mitochondria. In MDCK cells both mutants bind Bax as effectively as wild-type, demonstrating that Bax binding is not sufficient to prevent apoptosis. Previous ArticleNext Article Volume 15Issue 161 August 1996In this issue RelatedDetailsLoading ..." @default.
• W53848852 created "2016-06-24" @default.
• W53848852 creator A5015366291 @default.
• W53848852 creator A5037653873 @default.
• W53848852 creator A5043581775 @default.
• W53848852 creator A5066158171 @default.
• W53848852 creator A5072058741 @default.
• W53848852 creator A5085211692 @default.
• W53848852 date "1996-08-01" @default.
• W53848852 modified "2023-10-04" @default.
• W53848852 title "Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types." @default.
• W53848852 cites W1495162803 @default.
• W53848852 cites W1498586399 @default.
• W53848852 cites W1530373462 @default.
• W53848852 cites W1557371306 @default.
• W53848852 cites W1580368676 @default.
• W53848852 cites W1598875578 @default.
• W53848852 cites W1731365463 @default.
• W53848852 cites W1936689179 @default.
• W53848852 cites W1950456672 @default.
• W53848852 cites W1965069029 @default.
• W53848852 cites W1971124227 @default.
• W53848852 cites W1994803892 @default.
• W53848852 cites W1996563400 @default.
• W53848852 cites W1997208169 @default.
• W53848852 cites W2003694128 @default.
• W53848852 cites W2006659499 @default.
• W53848852 cites W2019572526 @default.
• W53848852 cites W2020721942 @default.
• W53848852 cites W2024582476 @default.
• W53848852 cites W2025818427 @default.
• W53848852 cites W2028625808 @default.
• W53848852 cites W2032361307 @default.
• W53848852 cites W2033847504 @default.
• W53848852 cites W2036274324 @default.
• W53848852 cites W2037473273 @default.
• W53848852 cites W2042928863 @default.
• W53848852 cites W2052341456 @default.
• W53848852 cites W2057257609 @default.
• W53848852 cites W2057713336 @default.
• W53848852 cites W2063176993 @default.
• W53848852 cites W2064967819 @default.
• W53848852 cites W2068807148 @default.
• W53848852 cites W2069326426 @default.
• W53848852 cites W2078457332 @default.
• W53848852 cites W2080022600 @default.
• W53848852 cites W2081948388 @default.
• W53848852 cites W2094657382 @default.
• W53848852 cites W2098712005 @default.
• W53848852 cites W2106697922 @default.
• W53848852 cites W2134979684 @default.
• W53848852 cites W2135894904 @default.
• W53848852 cites W2137022580 @default.
• W53848852 cites W2139970952 @default.
• W53848852 cites W2143772496 @default.
• W53848852 cites W2144695914 @default.
• W53848852 cites W2156276815 @default.
• W53848852 cites W2169404281 @default.
• W53848852 cites W2188651990 @default.
• W53848852 cites W2313812155 @default.
• W53848852 cites W2403265245 @default.
• W53848852 cites W26755955 @default.
• W53848852 cites W302073403 @default.
• W53848852 doi "https://doi.org/10.1002/j.1460-2075.1996.tb00788.x" @default.
• W53848852 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/452136" @default.
• W53848852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8861942" @default.
• W53848852 hasPublicationYear "1996" @default.
• W53848852 type Work @default.
• W53848852 sameAs 53848852 @default.
• W53848852 citedByCount "316" @default.
• W53848852 countsByYear W538488522012 @default.
• W53848852 countsByYear W538488522013 @default.
• W53848852 countsByYear W538488522014 @default.
• W53848852 countsByYear W538488522015 @default.
• W53848852 countsByYear W538488522016 @default.
• W53848852 countsByYear W538488522017 @default.
• W53848852 countsByYear W538488522018 @default.
• W53848852 countsByYear W538488522019 @default.
• W53848852 countsByYear W538488522020 @default.
• W53848852 countsByYear W538488522021 @default.
• W53848852 countsByYear W538488522022 @default.
• W53848852 countsByYear W538488522023 @default.
• W53848852 crossrefType "journal-article" @default.
• W53848852 hasAuthorship W53848852A5015366291 @default.
• W53848852 hasAuthorship W53848852A5037653873 @default.
• W53848852 hasAuthorship W53848852A5043581775 @default.
• W53848852 hasAuthorship W53848852A5066158171 @default.
• W53848852 hasAuthorship W53848852A5072058741 @default.
• W53848852 hasAuthorship W53848852A5085211692 @default.
• W53848852 hasBestOaLocation W538488521 @default.
• W53848852 hasConcept C161191863 @default.
• W53848852 hasConcept C41008148 @default.
• W53848852 hasConcept C86803240 @default.
• W53848852 hasConceptScore W53848852C161191863 @default.
• W53848852 hasConceptScore W53848852C41008148 @default.
• W53848852 hasConceptScore W53848852C86803240 @default.
• W53848852 hasIssue "16" @default.
• W53848852 hasLocation W538488521 @default.

• next