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- W53894220 endingPage "53" @default.
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- W53894220 abstract "Cardiovascular disease is the leading cause of death among women in the U.S., exceeding breast cancer mortality in women of all ages. Women present with cardiovascular disease a decade after men, and this has been attributed to the protective effect of female ovarian sex hormones that is lost after menopause. Animal and observational studies have shown beneficial effects of hormone therapy when it is initiated early in the perimenopausal period or before the development of significant atherosclerosis. However, randomized, placebo-controlled trials in older women have not shown any benefit in either primary prevention or secondary prevention of cardiovascular events, with a concerning trend toward harm. This review outlines the lessons learned from the basic science, animal, observational, and randomized trials, and then summarizes yet-unanswered questions of hormone therapy and cardiovascular risk." @default.
- W53894220 created "2016-06-24" @default.
- W53894220 creator A5031628494 @default.
- W53894220 creator A5036283255 @default.
- W53894220 creator A5075797873 @default.
- W53894220 date "2006-05-02" @default.
- W53894220 modified "2023-10-13" @default.
- W53894220 title "Hormone replacement therapy and the cardiovascular system lessons learned and unanswered questions." @default.
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- W53894220 doi "https://doi.org/10.1016/j.jacc.2005.10.076" @default.
- W53894220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16682298" @default.
- W53894220 hasPublicationYear "2006" @default.
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